Natural Products and Bioprospecting ( IF 4.8 ) Pub Date : 2022-08-16 , DOI: 10.1007/s13659-022-00356-x Lin Zhou 1 , Subiy Akbar 1 , Meng-Xi Wang 1 , He-Ping Chen 1 , Ji-Kai Liu 1
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Abstract
Chemical investigation on the medicinal fungus Ganoderma australe led to the identification of ten new nor-lanostane triterpenes, namely two hexa-nor ones, ganoaustratetraenones A (1) and B (2), five penta-nor ones, ganoaustraldehydes A–E (3–7), and three tetra-nor ones ganoaustrenoic acids A–C (8–10). The chemical structures along with the absolute configurations were determined by extensive spectroscopic analysis of 1D & 2D NMR and HRESIMS data. The postulated biosynthesis pathways of these compounds were proposed. Ganoaustraldehydes A (3) and B (4) showed moderate inhibition against nitric oxide production in RAW264.7 macrophage cells with the respective IC50 values of 32.5, 34.2 µM (the IC50 of positive control pyrrolidine dithiocarbamate was 20.0 µM).
Graphical Abstract
中文翻译：
来自药用真菌 Ganoderma australe 的四、五和六-羊毛甾烷三萜
摘要
对药用真菌Ganoderma australe的化学研究导致鉴定出 10 种新的去甲羊毛甾烷三萜，即两种六去甲二苯甲醚，ganoaustratetraenones A ( 1 ) 和 B ( 2 )，五种五去甲二甲醚，ganoaustraldehydes A-E ( 3 – 7 ), 和三个四去甲酸 a–C ( 8 – 10 )。通过对 1D 和 2D NMR 和 HRESIMS 数据的广泛光谱分析确定化学结构以及绝对构型。提出了这些化合物的假定生物合成途径。伽诺奥斯特醛 A ( 3 ) 和 B ( 4) 在 RAW264.7 巨噬细胞中显示出对一氧化氮产生的中度抑制作用，IC 50值分别为 32.5、34.2 µ M（阳性对照吡咯烷二硫代氨基甲酸酯的 IC 50为 20.0 µ M）。
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