Pronounced antiseizure activity of the subtype-selective GABAA positive allosteric modulator darigabat in a mouse model of drug-resistant focal epilepsy,CNS Neuroscience & Therapeutics

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Pronounced antiseizure activity of the subtype-selective GABAA positive allosteric modulator darigabat in a mouse model of drug-resistant focal epilepsy
CNS Neuroscience & Therapeutics ( IF 4.8 ) Pub Date : 2022-08-14 , DOI: 10.1111/cns.13927
Rachel Gurrell ₁ , Philip Iredale ₁ , Alexis Evrard ₂ , Venceslas Duveau ₂ , Céline Ruggiero ₂ , Corinne Roucard ₂

Affiliation

Darigabat is an α2/3/5 subunit-selective positive allosteric modulator of GABA_A receptors that has demonstrated broad-spectrum activity in several preclinical models of epilepsy as well as in a clinical photoepilepsy trial. The objective here was to assess the acute antiseizure effect of darigabat in the mesial temporal lobe epilepsy (MTLE) mouse model of drug-resistant focal seizures.

中文翻译：

亚型选择性 GABAA 正变构调节剂 darigabat 在耐药局灶性癫痫小鼠模型中的显着抗癫痫活性

Darigabat 是一种 α2/3/5 亚基选择性正向变构调节剂 GABA _A受体，已在多种临床前癫痫模型和临床光癫痫试验中显示出广谱活性。这里的目的是评估 darigabat 在耐药局灶性癫痫发作的内侧颞叶癫痫 (MTLE) 小鼠模型中的急性抗癫痫作用。

更新日期：2022-08-14

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