Review: the role of GSDMD in sepsis,Inflammation Research

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Review: the role of GSDMD in sepsis
Inflammation Research ( IF 4.8 ) Pub Date : 2022-08-15 , DOI: 10.1007/s00011-022-01624-9
Ruifei Shao _{1,

2} , Xiran Lou ₂ , Jinfang Xue ₂ , Deyuan Ning ₂ , Guobing Chen ₃ , Lihong Jiang ₄

Affiliation

Purpose

Gasdermin D (GSDMD) is a cytoplasmic protein that is encoded by the gasdermin family GSDMD gene and is the ultimate executor of pyroptosis. Pyroptosis is a mode of lysis and inflammation that regulates cell death, ultimately leading to cell swelling and rupture. In sepsis, a dysregulated host response to infection frequently results in hyperinflammatory responses and immunosuppression, eventually leading to multiple organ dysfunction. Pyroptosis regulates innate immune defenses and plays an important role in the process of inflammatory cell death, and the absence of any link in the entire pathway from GSDMD to pyroptosis causes bacterial clearance to be hampered. Under normal conditions, the process of pyroptosis occurs much faster than apoptosis, and the threat to the body is also much greater.

Materials and methods

We conducted a systematic review of relevant reviews and experimental articles using the keywords sepsis, Gasdermin D, and Pyroptosis in the PubMed, Scopus, Google Scholar, and Web of Science databases.

Conclusion

Combined with the pathogenesis of sepsis, it is not difficult to find that pyroptosis plays a key role in bacterial inflammation and sepsis. Therefore, GSDMD inhibitors may be used as targeted drugs to treat sepsis by reducing the occurrence of pyroptosis. This review mainly discusses the key role of GSDMD in sepsis.

中文翻译：

综述：GSDMD 在脓毒症中的作用

目的

Gasdermin D (GSDMD) 是一种细胞质蛋白，由 Gasdermin 家族 GSDMD 基因编码，是细胞焦亡的最终执行者。细胞焦亡是一种调节细胞死亡的裂解和炎症模式，最终导致细胞肿胀和破裂。在脓毒症中，宿主对感染的反应失调经常导致过度炎症反应和免疫抑制，最终导致多器官功能障碍。焦亡调节先天免疫防御，并在炎症细胞死亡过程中发挥重要作用，从 GSDMD 到焦亡的整个途径中缺乏任何环节，导致细菌清除受到阻碍。正常情况下，细胞焦亡的过程发生得比细胞凋亡快得多，对机体的威胁也大得多。