Abstract

Methyl 2-fluoro-3-hydroxypropanoate (MFHP) and its derivative methyl 3-chloro-2-fluoropropanoate (MCFP) are easily converted into methyl 2-fluoroacrylate (MFA). A roundabout strategy was put forward based on MFHP to overcome the shortcomings of MFA to extend its storage life and reduce its cost of shipment and storage. In our work, a novel and facile method for the synthesis of MFHP was developed based on Claisen salts and formaldehyde in water as followed: 37% formaldehyde aqueous (9.0 equiv.) was dropped into the aqueous of Claisen salt (1.0 equiv.) and NaHCO₃ (1.0 equiv.) at room temperature for 2-3 h to obtain MFHP in yield of 81.3%.

摘要

2-氟-3-羟基丙酸甲酯 (MFHP) 及其衍生物 3-氯-2-氟丙酸甲酯 (MCFP) 很容易转化为 2-氟丙烯酸甲酯 (MFA)。提出基于MFHP的迂回策略，克服MFA的缺点，延长其存储寿命，降低其运输和存储成本。在我们的工作中，基于克莱森盐和甲醛在水中开发了一种新颖简便的 MFHP 合成方法，如下所示：将 37% 甲醛水溶液（9.0 当量）滴入克莱森盐（1.0 当量）水溶液中，然后NaHCO ₃ (1.0当量)室温反应2-3 h得到MFHP，收率为81.3%。