锰掺杂单原子纳米酶复合金用于增强酶和光热治疗,Journal of Colloid and Interface Science

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锰掺杂单原子纳米酶复合金用于增强酶和光热治疗
Journal of Colloid and Interface Science ( IF 9.4 ) Pub Date : 2022-08-11 , DOI: 10.1016/j.jcis.2022.08.053
Boyang Shao ₁ , Yanlin Zhu ₁ , Yaqian Du ₁ , Dan Yang ₁ , Shili Gai ₂ , Fei He ₁ , Piaoping Yang ₂

Affiliation

作为一项新兴技术，纳米催化医学备受关注，特别是利用肿瘤中过量的 H2O 进行酶促反应的纳米催化医学。在各种候选催化剂中，单原子催化剂（SAC）表现出独特而出色的氧化还原反应性能，因为由单个金属原子组成的活性位点可以实现金属原子的最大利用，并出现明显放大的反应速率。在这里，我们通过煅烧掺锰沸石咪唑酯骨架（ZIF-8）开发了一种具有中空结构的MN（M = Mn，Zn）中心SAC，并应用聚乙二醇化来提高亲水性。根据酶促反应，MN（M = Mn，Zn）中心具有固有的过氧化物酶样活性，可以催化弱酸性肿瘤微环境中过度表达的H2O，并产生大量有毒的活性氧（ROS）例如用于治疗的羟基自由基。为了保持有效的治疗输出，我们将中空的 SAC 与 Au 集成，Au 可以消耗肿瘤中的葡萄糖并提供 H2O 作为过氧化物酶样活性的底物。更好的是，Au可以增强SAC的光热效应，并提供另一种非侵入性光热疗法（PTT）来促进肿瘤切除的效果。该平台为构建更高效的类过氧化物酶活性的肿瘤治疗提供了新思路。

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Mn-doped single atom nanozyme composited Au for enhancing enzymatic and photothermal therapy

As an emerging technology, nanocatalytic medicine attracts much attention, especially the ones according to the enzymatic reaction by using excess HO in the tumor. Among various candidates, single-atom catalyst (SAC) revealed unique and outstanding redox reaction performance, since the active sites consisting of single metal atoms may achieve the maximum utilization of metal atoms and emerge obviously amplified reaction rate. Here we developed an M−N (M = Mn, Zn) center-based SAC with a hollow structure by calcination of Mn-doped zeolitic imidazolate frameworks (ZIF-8), and PEGylation was applied to improve the hydrophilicity. According to the enzymatic reaction, the M−N (M = Mn, Zn) centers have an inherent peroxidase-like activity to catalyze over-expressed HO in the weak acidic tumor microenvironment and generate a large amount of toxic reactive oxygen species (ROS) like hydroxyl radicals for therapy. To keep efficient therapeutic output, we integrated the hollow SAC with Au which could expend the glucose in tumor and supply HO as the substrate of peroxidase-like activity. Better yet, Au may boost the photothermal effect of SAC and offer another non-invasive photothermal therapy (PTT) to promote the effect of tumor removal. This platform provided a new idea for the construction of more efficient peroxidase-like activity in tumor therapy.

更新日期：2022-08-11

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