有机和无机催化下螺吡唑的合成,Current Organic Chemistry

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有机和无机催化下螺吡唑的合成
Current Organic Chemistry ( IF 1.7 ) Pub Date : 2022-05-19 , DOI: 10.2174/1385272826666220517220157
Thoraya A. Farghaly ₁ , Sami A. Al-Hussain ₂ , Magdi E. A. Zaki ₂ , Basim H. Asghar ₃ , Zeinab A. Muhammad ₄

Affiliation

：螺吡唑具有许多生物活性，例如抗肿瘤、血管舒张、镇痛、磷酸二酯酶抑制剂、醛固酮拮抗剂、合成代谢、雄激素、抗炎、促孕和保盐活性，它们还在多巴胺能细胞死亡中发挥神经保护作用。已经做出许多努力来获得这些具有高产率和优异的区域选择性、非对映选择性和对映选择性的衍生物。大多数螺拉唑合成方法在有机催化剂存在下以良好或优异的产率进行，例如角酰胺、NHC 预催化剂、吡咯衍生物、双恶唑啉等。DMAP、DABCO、硫脲衍生物、DBU、乙酸和喹啉催化剂。此外，无机和有机金属催化剂已被证明在以优异的收率合成各种类型的螺吡唑方面的有效性。因此，在这篇综述中，我们汇总了 2020 年至 2012 年间在各种类型的催化剂（如有机、无机和金属有机催化剂）存在下合成螺吡唑的所有引文。这篇综述文章是对感兴趣的研究人员的有用汇编在螺吡唑衍生物的合成中，并将帮助他们选择合适的催化剂来制备螺吡唑。

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Synthesis of Spiropyrazoles Under Organic and Nonorganic Catalysis

: Spiropyrazoles display many biological activities such as antitumor, vasodilation, analgesic, phosphodiesterase inhibitors, aldosterone antagonistic, anabolic, androgenic, antiinflammatory, progestational and salt-retaining activities, and they also exert neuroprotection in dopaminergic cell death. Many efforts have been made to obtain these derivatives with high yield and excellent regio-, diastereo- and enantioselectivities. Most of the spiroprazole synthesis methods were proceeded in good to excellent yield in the presence of organic catalysts, such as squaramide, NHC pre-catalyst, pyrrole derivatives, bis-oxazoline, etc. DMAP, DABCO, thiourea derivatives, DBU, acetic acid and quinoline catalysts. In addition, the inorganic and organometallic catalysts have been proven their efficiency in the synthesis of various types of spiro-pyrazoles in excellent yield. Thus, in this review, we have compiled all citations for the synthesis of spiropyrazoles in the presence of various types of catalysts such as organic, inorganic, and metalorganic catalysts in the range 2020 to 2012. This review article is a useful compilation for researchers interested in the synthesis of spiropyrazole derivatives and will assist them in selecting appropriate catalysts for the preparation of their spiropyrazoles.

更新日期：2022-05-19

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