As significant biocatalysts, natural enzymes have exhibited a vast range of applications in biocatalytic reactions. However, the “always-on” natural enzyme activity is not beneficial for the regulation of catalytic processes, which limits their bio-applications. Recently, it has been extensively reported that various organic artificial enzymes exhibit prominent absorption and controlled activity under illumination, which not only creates a series of light-responsive catalytic platforms but also plays a key role in biosensing and biomedical research. To provide novel ideas for the design of artificial enzymes, we conduct this review to highlight the recent progress of light-responsive organic artificial enzymes (LOA-Enz). The specific photoresponse mechanism and various bio-applications of LOA-Enz are also presented in detail. Furthermore, the remaining challenges and future perspectives in this field are discussed.

作为重要的生物催化剂，天然酶在生物催化反应中表现出广泛的应用。然而，“永远在线”的天然酶活性不利于催化过程的调节，这限制了它们的生物应用。近年来，各种有机人工酶在光照下表现出显着的吸收和可控活性被广泛报道，这不仅创造了一系列光响应催化平台，而且在生物传感和生物医学研究中发挥着关键作用。为了为人工酶的设计提供新的思路，我们进行了这篇综述，以突出光响应有机人工酶（LOA-Enz）的最新进展。还详细介绍了 LOA-Enz 的具体光响应机制和各种生物应用。此外，