D–A 型 NIR-II 有机分子：增强荧光亮度的策略及其在 NIR-II 荧光成像导航光热疗法中的应用,Advanced Healthcare Materials

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D–A 型 NIR-II 有机分子：增强荧光亮度的策略及其在 NIR-II 荧光成像导航光热疗法中的应用
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2022-08-09 , DOI: 10.1002/adhm.202201158
Yan Chen ₁ , Shangyu Chen ₂ , Haoli Yu ₁ , Yuesong Wang ₁ , Mengyuan Cui ₁ , Peng Wang ₃ , Pengfei Sun ₂ , Min Ji ₁

Affiliation

NIR-II荧光成像（NIR-II FI）和光热疗法（PTT）由于高分辨率和深部组织成像、可忽略的侵入性和高效治疗而在肿瘤精确诊断和有效治疗方面受到广泛关注。尽管已经为 NIR-II FI 和 PTT 设计并进行了许多荧光分子，但研究人员仍然面临着开创一些合理设计指南以提高荧光亮度的巨大挑战。有机 D-A 型分子，包括小分子和共轭聚合物，由于其可调谐且易于功能化的化学结构，可以设计和开发以提高荧光亮度，从而允许分子定制光物理特性。在这篇评论中，系统地介绍了用于增强荧光亮度的D-A型小分子和共轭聚合物的开发和设计策略的一些途径。同时，对基于NIR-II FI的单成像或多成像技术辅助的PTT和基于PTT的联合治疗（如PDT、化疗或气体治疗）的一些应用进行了分类和详细介绍。最后，总结和讨论了 NIR-II 有机分子在 NIR-II FI 导航 PTT 中的当前问题和挑战，为 NIR-II FI 导航 PTT 的 NIR-II 有机分子的未来发展方向提供了一些指导。或气体疗法）在基于 NIR-II FI 的单一或多成像技术的协助下进行了分类和详细介绍。最后，总结和讨论了 NIR-II 有机分子在 NIR-II FI 导航 PTT 中的当前问题和挑战，为 NIR-II FI 导航 PTT 的 NIR-II 有机分子的未来发展方向提供了一些指导。或气体疗法）在基于 NIR-II FI 的单一或多成像技术的协助下进行了分类和详细介绍。最后，总结和讨论了 NIR-II 有机分子在 NIR-II FI 导航 PTT 中的当前问题和挑战，为 NIR-II FI 导航 PTT 的 NIR-II 有机分子的未来发展方向提供了一些指导。

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D–A Type NIR-II Organic Molecules: Strategies for the Enhancement Fluorescence Brightness and Applications in NIR-II Fluorescence Imaging-Navigated Photothermal Therapy

NIR-II fluorescence imaging (NIR-II FI) and photothermal therapy (PTT) have received broad attentions in precise tumor diagnosis and effective treatment attributed to high-resolution and deep tissue imaging, negligible invasivity, and high-efficiency treatment. Although many fluorescent molecules have been designed and conducted for NIR-II FI and PTT, it is still an enormous challenge for researchers to pioneer some rational design guidelines to improve fluorescence brightness. Organic D–A-type molecules, including small molecules and conjugated polymers, can be designed and developed to improve fluorescence brightness due to their tunable and easy functionalized chemical structures, allowing molecules tailored photophysical properties. In this review, some approaches to the development and design strategies of D–A type small molecules and conjugated polymers for the enhancement of fluorescence brightness are systemically introduced. Meanwhile, some applications of PTT and PTT-based combination therapy (such as PDT, chemotherapy, or gas therapy) assisted by NIR-II FI-based single or multiimaging technologies are classified and represented in detail as well. Finally, the current issues and challenges of NIR-II organic molecules in NIR-II FI-navigated PTT are summarized and discussed, which gives some guidelines for the future development direction of NIR-II organic molecules for NIR-II FI-navigated PTT.

更新日期：2022-08-09

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