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Tumor inhibitory effect via immunostimulating activities of a rhamnogalacturonan-I-rich polysaccharide isolated from turmeric (Curcuma longa L.)
Journal of Food Biochemistry ( IF 3.5 ) Pub Date : 2022-08-07 , DOI: 10.1111/jfbc.14362
Eun Hye Choi 1 , Seung-U Son 1, 2 , Kwang-Soon Shin 1
Affiliation  

In this study, a turmeric polysaccharide (TP-0) was isolated through hot water extraction and ethanol precipitation to produce a novel active polysaccharide from turmeric other than curcuminoids. TP-0 was found to be primarily composed of eight different monosaccharides, such as galactose (15.9%), galacturonic acid (15.2%), arabinose (11.4%), and rhamnose (9.7%), which are typical rhamnogalacturonan (RG)-I sugars. When stimulated with TP-0, peritoneal macrophages secreted a variety of immunostimulatory cytokines. In addition, intravenous and oral administration of TP-0 significantly enhanced the natural killer (NK) cells and cytotoxic T lymphocyte (CTL)-mediated cytotoxicity against tumor cells. In an assay for lung cancer induced by Colon26-M3.1 carcinoma, prophylactic intravenous and oral administration of TP-0 effectively inhibited lung cancer. These findings reveal that TP-0, a typical RG-I-type polysaccharide that is isolated from turmeric, has potent anti-metastatic activities, and these activities are linked to various immunological factors such as macrophages, NK cells, and CTL.

中文翻译:

从姜黄(Curcuma longa L.)中分离出的富含鼠李糖半乳糖醛酸-I的多糖的免疫刺激活性抑制肿瘤

在这项研究中,通过热水提取和乙醇沉淀分离出一种姜黄多糖 (TP-0),以从姜黄中生产除姜黄素以外的新型活性多糖。发现TP-0主要由八种不同的单糖组成,如半乳糖(15.9%)、半乳糖醛酸(15.2%)、阿拉伯糖(11.4%)和鼠李糖(9.7%),它们是典型的鼠李糖半乳糖醛酸(RG)-我加糖。当用 TP-0 刺激时,腹腔巨噬细胞分泌多种免疫刺激细胞因子。此外,TP-0 的静脉内和口服给药显着增强了自然杀伤 (NK) 细胞和细胞毒性 T 淋巴细胞 (CTL) 介导的对肿瘤细胞的细胞毒性。在结肠26-M3.1癌诱导的肺癌试验中,预防性静脉内和口服TP-0有效抑制肺癌。
更新日期:2022-08-07
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