C–H acylation of aniline derivatives with α-oxocarboxylic acids using ruthenium catalyst,Organic & Biomolecular Chemistry

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C–H acylation of aniline derivatives with α-oxocarboxylic acids using ruthenium catalyst
Organic & Biomolecular Chemistry ( IF 2.9 ) Pub Date : 2022-08-08 , DOI: 10.1039/d2ob01212j
Qiong Liu ₁ , Jia-Yuan Yong ₁ , Jing Zhang ₂ , Tao Ban ₁ , Xu-Qin Li ₁

Affiliation

An efficient and convenient synthetic strategy for ruthenium(II)-catalyzed ortho-acylation of N-(2-pyridyl)-anilines using α-oxycarboxylic acids as acyl sources is described. The procedure can smoothly proceed under mild conditions, showing good functional group tolerance. Valuable ortho-acylated aniline products have been obtained with moderate to good yields. Furthermore, the reaction could be easily scaled up to the gram scale.

中文翻译：

使用钌催化剂对苯胺衍生物与α-氧代羧酸进行C-H酰化

描述了一种使用 α-羟基羧酸作为酰基源的钌 ( II ) 催化的N- (2-吡啶基)-苯胺邻位酰化的有效且方便的合成策略。该过程可以在温和的条件下顺利进行，表现出良好的官能团耐受性。以中等至良好的收率获得了有价值的邻酰化苯胺产品。此外，反应可以很容易地放大到克级。

更新日期：2022-08-08

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