Sirtuins perform an important effect on the neural cell fate following stroke. Several mechanisms that have been correlated with stroke are oxidative stress, apoptosis, necrosis and autophagy. Autophagy is usually regarded as unitary of the neural cell survival mechanisms. Recently, the importance of the sirtuins effect on autophagy by antioxidant agents for stroke treatment mentioned in various studies. One of these agents is melatonin. Melatonin can modulate autophagy by changing on sirtuin pathways. Melatonin and its metabolites adjust various sirtuins pathways related to apoptosis, proliferation, metastases, autophagy and inflammation in case of stroke. In this review, we will discuss about the modulation of autophagy by melatonin via sirtuins in stroke.

Sirtuins 对中风后的神经细胞命运有重要影响。与中风相关的几种机制是氧化应激、细胞凋亡、坏死和自噬。自噬通常被认为是神经细胞存活机制的统一体。最近，各种研究中都提到了抗氧化剂对自噬的抗氧化作用对自噬的重要性。其中一种药物是褪黑激素。褪黑激素可以通过改变sirtuin途径来调节自噬。褪黑激素及其代谢物在中风的情况下调节与细胞凋亡、增殖、转移、自噬和炎症相关的各种去乙酰化酶途径。在这篇综述中，我们将讨论褪黑激素通过 sirtuins 在中风中对自噬的调节作用。