NADPH 氧化酶 NOX4 调节氧化还原和代谢稳态，预防 HCC 进展,Hepatology

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NADPH 氧化酶 NOX4 调节氧化还原和代谢稳态，预防 HCC 进展
Hepatology ( IF 12.9 ) Pub Date : 2022-08-03 , DOI: 10.1002/hep.32702
Irene Peñuelas-Haro _{1,

2} , Rut Espinosa-Sotelo _{1,

2} , Eva Crosas-Molist ₁ , Macarena Herranz-Itúrbide _{1,

2} , Daniel Caballero-Díaz _{1,

2} , Ania Alay _{3,

4} , Xavier Solé _{3,

4,

5} , Emilio Ramos _{2,

6,

7} , Teresa Serrano _{2,

7,

8} , María L Martínez-Chantar _{2,

9} , Ulla G Knaus ₁₀ , José M Cuezva _{11,

12} , Antonio Zorzano _{13,

14,

15} , Esther Bertran _{1,

2} , Isabel Fabregat _{1,

2,

16}

Affiliation

TGF-β and Cancer Group , Oncobell Program , Bellvitge Biomedical Research Institute , L'Hospitalet de Llobregat , Barcelona , Spain.
CIBEREHD , ISCIII , Madrid , Spain.
Unit of Bioinformatics for Precision Oncology , Catalan Institute of Oncology , L'Hospitalet de Llobregat , Barcelona , Spain.
Preclinical and Experimental Research in Thoracic Tumors , Oncobell Program , IDIBELL, L'Hospitalet de Llobregat , Barcelona , Spain.
Molecular Biology CORE , Center for Biomedical Diagnostics, Hospital Clínic of Barcelona , Translational Genomics and Targeted Therapies in Solid Tumors, August Pi i Sunyer Biomedical Research Institute , Barcelona , Spain.
Department of Surgery, Liver Transplant Unit , University Hospital of Bellvitge , Barcelona , Spain.
Faculty of Medicine and Health Sciences , University of Barcelona, L'Hospitalet de Llobregat , Barcelona , Spain.
Pathological Anatomy Service , University Hospital of Bellvitge , Barcelona , Spain.
Liver Disease Lab , Center for Cooperative Research in Biosciences , Basque Research and Technology Alliance , Bizkaia Technology Park , Spain.
Conway Institute , University College Dublin , Dublin , Ireland.
Center for Molecular Biology "Severo Ochoa," Autonoma University of Madrid , Madrid , Spain.
CIBERER, ISCIII , Madrid , Spain.
Biochemistry and Molecular Biomedicine Department , University of Barcelona , Barcelona , Spain.
Institute of Research in Biomedicine , Barcelona Institute of Science and Technology (BIST) , Barcelona , Spain.
CIBERDEM, ISCIII , Madrid , Spain.
Physiological Sciences Department , University of Barcelona , Barcelona , Spain.

NADPH 氧化酶 NOX4 在 HCC 中发挥肿瘤抑制功能。沉默 NOX4 赋予 HCC 细胞更高的增殖和迁移能力，并增加其在小鼠异种移植物中的体内致瘤潜力。NOX4 基因缺失在 HCC 中很常见，与较高的肿瘤分级以及较差的无复发率和总生存率相关。然而，尽管越来越多的证据表明 NOX4 在 HCC 中具有保护性调节作用，但 NOX4 控制的细胞过程尚不清楚。因此，这项工作的目的是更好地了解 NOX4 在 HCC 中调节的分子机制，以解释其肿瘤抑制作用。

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更新日期：2022-08-03

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