Apolipoprotein A4 Restricts Diet-Induced Hepatic Steatosis via SREBF1-Mediated Lipogenesis and Enhances IRS-PI3K-Akt Signaling,Molecular Nutrition & Food Research

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Apolipoprotein A4 Restricts Diet-Induced Hepatic Steatosis via SREBF1-Mediated Lipogenesis and Enhances IRS-PI3K-Akt Signaling
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2022-07-31 , DOI: 10.1002/mnfr.202101034
Cheng Cheng _{1,

2} , Xiao-Huan Liu ₃ , Jing He _{1,

2} , Jing Gao ₄ , Jin-Ting Zhou _{1,

2} , Jing-Na Fan _{1,

2} , Xi Jin _{1,

2} , Jianbo Zhang _{1,

2} , Liao Chang _{1,

2} , Zijun Xiong _{1,

2} , Jun Yu ₅ , Shengbin Li _{1,

2} , Xiaoming Li ₃

Affiliation

Hepatic steatosis and insulin resistance (IR) are risk factors for many metabolic syndromes such as NAFLD and T2DM. ApoA4 improves glucose hemostasis by increasing glucose-stimulated insulin secretion and glucose uptake via PI3K-Akt activation in adipocytes. However, whether ApoA4 has an effect on hepatic steatosis or IR remains unclear.

中文翻译：

载脂蛋白 A4 通过 SREBF1 介导的脂肪生成限制饮食诱导的肝脂肪变性并增强 IRS-PI3K-Akt 信号传导

肝脏脂肪变性和胰岛素抵抗 (IR) 是许多代谢综合征（如 NAFLD 和 T2DM）的危险因素。ApoA4 通过脂肪细胞中的 PI3K-Akt 激活增加葡萄糖刺激的胰岛素分泌和葡萄糖摄取，从而改善葡萄糖止血。然而，ApoA4 是否对肝脂肪变性或 IR 有影响仍不清楚。

更新日期：2022-07-31

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