Sprayable Antibacterial Hydrogels by Simply Mixing of Aminoglycoside Antibiotics and Cellulose Nanocrystals for the Treatment of Infected Wounds,Advanced Healthcare Materials

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Sprayable Antibacterial Hydrogels by Simply Mixing of Aminoglycoside Antibiotics and Cellulose Nanocrystals for the Treatment of Infected Wounds
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2022-08-06 , DOI: 10.1002/adhm.202201286
Lin Li ₁ , Xuejing Cheng ₂ , Quan Huang ₁ , Yiyun Cheng ₂ , Jianru Xiao ₁ , Jingjing Hu ₂

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Antibiotic hydrogels with sustained release profiles are recognized as promising candidates to treat local bacterial infections with reduced adverse effects. However, it still remains challenging for clinical translation of these antibiotic gels due to safety concern of gel ingredients, complicated synthesis and fabrication procedures, and unsatisfactory rheological properties for practical uses in vivo. Herein, the preparation of a type of sprayable hydrogels by ionic interactions between aminoglycosides and cellulose nanocrystals (CNC) is proposed for the treatment of local infections such as bacteria-infected wounds. The CNC-based hydrogels are applicable for all kinds of aminoglycoside antibiotics and show excellent gel stability and rheological behaviors such as shear thinning and fast self-healing, allowing facile administration by injection or spraying. The hydrogels exhibit efficient antibacterial activity both in vitro and in vivo, and accelerate bacteria-infected wounds by spraying on the infected area. The proposed hydrogels by simply mixing of aminoglycosides and CNC provide great prospects for clinical translation in the treatment of local infections.

中文翻译：

氨基糖苷类抗生素和纤维素纳米晶体的简单混合可喷涂抗菌水凝胶用于治疗感染伤口

具有持续释放特性的抗生素水凝胶被认为是治疗局部细菌感染并减少不良反应的有前途的候选药物。然而，由于凝胶成分的安全性问题、复杂的合成和制造程序以及体内实际使用的流变学性能不令人满意，这些抗生素凝胶的临床转化仍然具有挑战性。在此，提出了一种通过氨基糖苷类和纤维素纳米晶体 (CNC) 之间的离子相互作用制备的可喷雾水凝胶，用于治疗局部感染，例如细菌感染的伤口。基于CNC的水凝胶适用于各种氨基糖苷类抗生素，并表现出优异的凝胶稳定性和流变行为，如剪切稀化和快速自愈，允许通过注射或喷雾方便地给药。水凝胶在体外和体内均表现出高效的抗菌活性，并通过喷洒在感染区域来加速细菌感染的伤口。通过将氨基糖苷类和 CNC 简单混合所提出的水凝胶为治疗局部感染的临床转化提供了广阔的前景。

更新日期：2022-08-06

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