Rapid and Economical Chemoselective Metabolomics Using Boronate Ester Formation on a Monolithic Substrate,Angewandte Chemie International Edition

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Rapid and Economical Chemoselective Metabolomics Using Boronate Ester Formation on a Monolithic Substrate
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2022-08-03 , DOI: 10.1002/anie.202208138
Xiangyu Wang ₁ , Peirong Bai ₁ , Ziying Li ₁ , Quan-Fei Zhu ₂ , Zhenwei Wei ₁ , Yu-Qi Feng _{1,

2}

Affiliation

A rapid and economical chemoselective labeling strategy was established involving a boronate ester reaction on a monolithic substrate. Only 15 minutes is required to complete the strategy and boron allows for recognition of labeled metabolites with no need for expensive additional isotopic encoding. The sensitivity was enhanced up to 1 600 times compared with non-labeled liquid chromatography–mass spectrometry methods.

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