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Biosensing strategies (approaches) for diagnosis and monitoring of multiple sclerosis
Talanta ( IF 5.6 ) Pub Date : 2022-08-04 , DOI: 10.1016/j.talanta.2022.123794
Marina Serin 1 , Pinar Kara 2
Affiliation  

Multiple sclerosis is a recurrent and progressive inflammatory autoimmune disease causing demyelination in the central nervous system. Nowadays, the number of MS patients is increasing, but the diagnostic process and disease management are still quite difficult and costly and time consuming. The combination of methods used for clinical MS diagnosis mainly relies on MRI, that cannot be used as routine analysis. Classical methods of biological liquids analysis used for disease diagnosis and monitoring, include electrophoretic and labeled antibody-based techniques requiring professional personnel for analysis performing and results interpretation. In line with that, there is a need for reliable, sensitive and cost-effective methods that would be easier to take for both the staff and the patient. Biosensors application for MS biomarkers detection would provide such advantages.

中文翻译:


用于诊断和监测多发性硬化症的生物传感策略(方法)



多发性硬化症是一种复发性和进行性炎症性自身免疫性疾病,可导致中枢神经系统脱髓鞘。如今,多发性硬化症患者的数量不断增加,但诊断过程和疾病管理仍然相当困难、昂贵且耗时。用于临床 MS 诊断的方法组合主要依赖于 MRI,不能用作常规分析。用于疾病诊断和监测的生物液体分析的经典方法包括电泳和基于标记抗体的技术,需要专业人员进行分析执行和结果解释。与此一致,需要可靠、灵敏且具有成本效益的方法,这些方法对工作人员和患者来说都更容易采用。用于 MS 生物标志物检测的生物传感器应用程序将提供这些优势。
更新日期:2022-08-04
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