The Raman spectrum of a single erythrocyte captured by a microfluidic chip was recorded to determine the conformation of hemoglobin under conditions similar to the hemodynamics of a blood vessel. Amplitude changes in the Raman spectrum at 1355, 1375, 1552, 1620, 1585 and 1637 cm−1 reflect changes in pO₂ due to O₂ binding to hemoglobin heme.

中文翻译：

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通过拉曼光谱对微流控芯片中捕获的单个人红细胞进行血红蛋白构象检测

记录由微流控芯片捕获的单个红细胞的拉曼光谱，以确定在类似于血管血流动力学的条件下血红蛋白的构象。拉曼光谱在 1355、1375、1552、1620、1585 和 1637 cm-1 处的幅度变化反映了由于 O ₂与血红蛋白血红素结合而导致的 pO _2变化。