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Bivalent transition metal complexes of pyridine-2,6-dicarbohydrazide: Structural characterization, cyclic voltammetry and biological studies
Journal of Molecular Structure ( IF 4.0 ) Pub Date : 2022-08-02 , DOI: 10.1016/j.molstruc.2022.133852
Abdullah H. Mannaa , Rania R. Zaky , Esam A. Gomaa , Mahmoud N. Abd El-Hady

A series of Co2+, Cu2+ and Cd2+ solid chelates are prepared from pyridine-2,6-dicarbohydrazide (H2P). All compounds are elucidated by spectroscopic and microscopic techniques (IR, UV–visible, 1HNMR, 13C NMR, ESR, XRD, MS spectra, SEM and EDX). In addition, they are investigated by elemental, magnetic and thermal (TG/DTA) analyses. The Gaussian 09 program has been employed to build up the best molecular structure for all the complexes based on the DFT method. The impact of complex formation at the electrochemical conduct of the Cd2+ cation has been investigated using cyclic voltammetry in absence/presence of H2P. Finally, biological investigations involving antimicrobial, antioxidant, erythrocyte hemolysis, DNA-binding and cytotoxicityare screened for all samples.



中文翻译:

吡啶-2,6-二碳酰肼的二价过渡金属配合物:结构表征、循环伏安法和生物学研究

一系列Co 2+、Cu 2+和Cd 2+固体螯合物由吡啶-2,6-二碳酰肼(H 2 P)制备。所有化合物均通过光谱和显微技术(IR、UV-可见光、1 HNMR、13 C NMR、ESR、XRD、MS 光谱、SEM 和 EDX)进行了分析。此外,它们还通过元素、磁性和热 (TG/DTA) 分析进行研究。Gaussian 09 程序已被用于建立基于 DFT 方法的所有配合物的最佳分子结构。已经使用循环伏安法在不存在/存在H 2的情况下研究了络合物形成对Cd 2+阳离子电化学传导的影响P. 最后,对所有样品进行了涉及抗微生物、抗氧化剂、红细胞溶血、DNA 结合和细胞毒性的生物学研究。

更新日期:2022-08-02
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