Paper items from historical archives and libraries are frequently colonized by biodeteriogens, the management of which is a major concern. Essential oil Volatile Organic Compounds (VOCs) of thymol, carvacrol and eugenol, with high levels of antimicrobial and insect repellent activity, were stabilized within crystalline networks of β-cyclodextrins and phenazine-based cocrystals, as a new tool for the control of paper-degrading agents. These formulations were obtained via solvent-free methodologies and resulted as easy handling powders, suitable for the treatment of paper items by indirect contact. Their antimicrobial activity was evaluated on the following species isolated from a book depository at Forte Belvedere (Florence, IT): Alternaria alternata, Aspergillus sp., Cladosporium sp., Trichoderma orientale, Metschnikowia sp., and Bacillus sp. Both formulates displayed a significant antimicrobial activity in vitro, with cocrystals showing higher efficacy than β-cyclodextrins. The formulates were also tested against the pest Lasioderma serricorne, towards which the cocrystals entrapping carvacrol and thymol exhibited repellent activity. Overall, the phenazine-carvacrol cocrystal was the best-performing formulate, also giving favourable outcomes in terms of antifungal activity in an on-paper in vitro experiment designed to reproduce on a small-scale the critical conditions of an infested archive. These promising results pave the way towards further experimentations of VOC-based solid formulates, to shed light on such products applicability for the preservation of paper items.

来自历史档案馆和图书馆的纸质物品经常被生物污染物定殖，其管理是一个主要问题。百里香酚、香芹酚和丁子香酚的挥发性有机化合物 (VOC) 具有高水平的抗菌和驱虫活性，在 β-环糊精和吩嗪基共晶体的结晶网络中稳定，作为控制纸张的新工具-降解剂。这些配方是通过无溶剂方法获得的，并制成易于处理的粉末，适用于通过间接接触处理纸制品。对从 Forte Belvedere (Florence, IT) 的书库中分离出的以下物种评估了它们的抗菌活性：Alternaria alternata、Aspergillus sp.、Cladosporium sp.、Trichoderma orientale、Metschnikowia sp.和Bacillus sp. 两种制剂在体外都显示出显着的抗菌活性，共晶体显示出比β-环糊精更高的功效。该制剂还针对害虫Lasioderma serricorne进行了测试，捕获香芹酚和百里酚的共晶体对这种害虫表现出驱避活性。总的来说，吩嗪-香芹酚共晶体是表现最好的配方，在体外纸上的抗真菌活性方面也产生了良好的结果旨在小规模复制受感染档案的关键条件的实验。这些有希望的结果为进一步试验基于 VOC 的固体配方铺平了道路，以阐明此类产品在保存纸制品方面的适用性。