Surface-enhanced Raman scattering (SERS) utilizing plasmonic metals coupled with transition metal dichalcogenide (TMD) has received increasing attention in bio-applications due to the synergistically enhanced detection sensitivity. However, there have been several issues to be addressed such as strong SERS background signals and low Raman intensities of analytes. In this study, we report a novel approach for high SERS performance based on anisotropic hybrid plasmonic nanostructures of gold nanoworms (Au NWs) conjugated with 2D Molybdenum disulfide (MoS₂) nanosheets. To significantly enhance the SERS enhancement factor (EF), we optimized the gap between Au NWs and MoS₂ to ~2 nm by controlling the thickness of polydopamine (PDA). Thus, giant localized electric field enhancement and synergistic coupling effect occurred in the hybrid plasmonic nanostructures, generating abundant hot spots. Consequently, SERS EF of the order of ~10⁷ was achieved, which was 10⁴ times higher than that of colloidal Au nanoparticles. Further, we showcase that our AuNW@MoS₂ can detect the 10⁻¹⁰ M level thiram, a typical pesticide, under soil-pollutant muddy condition, evidencing the powerful multimodal sensory platform of our hybrid substrates. This work provides new insight into the rational design of plasmon-coupled 2D nanohybrids for high-performance SERS substrates with a premise for the practical and viable biosensing applications.

由于协同增强的检测灵敏度，利用等离子体金属与过渡金属二硫属化物 (TMD) 耦合的表面增强拉曼散射 (SERS) 在生物应用中受到越来越多的关注。然而，有几个问题需要解决，例如强 SERS 背景信号和分析物的低拉曼强度。_{在这项研究中，我们报告了一种基于与二维二硫化钼 (MoS 2} ) 纳米片共轭的金纳米线虫 (Au NW) 的各向异性混合等离子体纳米结构的高 SERS 性能的新方法。_{为了显着提高 SERS 增强因子 (EF)，我们优化了 Au NW 和 MoS 2}之间的间隙通过控制聚多巴胺 (PDA) 的厚度达到约 2 nm。因此，在混合等离子体纳米结构中发生了巨大的局部电场增强和协同耦合效应，产生了丰富的热点。^{因此，实现了约10 7}量级的SERS EF，比胶体Au纳米颗粒高10 ^4倍。此外，我们展示了我们的 AuNW@MoS ₂可以检测到 10 ^-10M 级福美双，一种典型的农药，在土壤污染物泥泞的条件下，证明了我们的混合基质强大的多模式感官平台。这项工作为合理设计用于高性能 SERS 基底的等离子体耦合二维纳米杂化物提供了新的见解，为实际可行的生物传感应用奠定了基础。