The Synthesis of 5,6-dihydrobenzo[4,5]imidazo[2,1-a]isoquinoline Derivatives via Metal-Free Radical Cascade Pathway,Advanced Synthesis & Catalysis

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The Synthesis of 5,6-dihydrobenzo[4,5]imidazo[2,1-a]isoquinoline Derivatives via Metal-Free Radical Cascade Pathway
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2022-07-29 , DOI: 10.1002/adsc.202200571
Youlu pan ₁ , Jinghao Xu ₁ , Hongjie Zhang ₁ , Rongrong Hao ₁ , Zhengrong Shen ₁ , Wenhai Huang ₁

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A metal-free radical relay addition/cyclization of activated alkenes with ethers, cycloalkanes, toluenes, and alcohols has been achieved, leading to a range of functionalization of 5,6-dihydrobenzo[4,5]imidazo[2,1-a]isoquinolines with the yield of 43% - 84%. This protocol exhibits advantages of metal-free, base-free, and shorter reaction time.

中文翻译：

通过无金属自由基级联途径合成5,6-二氢苯并[4,5]咪唑并[2,1-a]异喹啉衍生物

已经实现了活化烯烃与醚、环烷烃、甲苯和醇的金属自由基中继加成/环化，导致了 5,6-二氢苯并[4,5]咪唑并[2,1- a ]的一系列功能化异喹啉的收率为 43% - 84%。该协议具有无金属、无碱基和更短反应时间的优点。

更新日期：2022-07-29

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