Electrocarboxylation of Aryl Epoxides with CO2 for the Facile and Selective Synthesis of β-Hydroxy Acids,Angewandte Chemie International Edition

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Electrocarboxylation of Aryl Epoxides with CO2 for the Facile and Selective Synthesis of β-Hydroxy Acids
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2022-07-29 , DOI: 10.1002/anie.202207746
Yanwei Wang ₁ , Shunyao Tang ₁ , Guoqing Yang ₁ , Siyi Wang ₁ , Dengke Ma ₁ , Youai Qiu ₁

Affiliation

A general and efficient method for the electroreductive carboxylation of aryl epoxides with CO₂ has been developed to provide β-hydroxy acids. The method exhibited broad substrate scope, could be extended to cyclic ethers with larger rings, and proved to be a powerful approach to the late-stage carboxylation of natural product derivatives and drug molecules.

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