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Construction of Quaternary Allylic Amino Acid Derivatives through Palladium-Catalyzed Allylic Alkylation Reaction of Azlactones with Vinyl Aziridine
Synthesis ( IF 2.2 ) Pub Date : 2022-07-27 , DOI: 10.1055/a-1878-8084
Kexin Huang 1 , Zhao-Yang Chen 1 , Xue-Guo Liu 1 , Hong-Yong Ye 1 , Wen-Chao Gao 2
中文翻译：
钯催化烯丙内酯与乙烯基氮丙啶的烯丙基烷基化反应构建季烯丙基氨基酸衍生物
更新日期：2022-07-28
Synthesis ( IF 2.2 ) Pub Date : 2022-07-27 , DOI: 10.1055/a-1878-8084
Kexin Huang 1 , Zhao-Yang Chen 1 , Xue-Guo Liu 1 , Hong-Yong Ye 1 , Wen-Chao Gao 2
Affiliation
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A highly efficient Pd-catalyzed allylic alkylation reaction of azlactones with vinyl aziridine has been achieved for the first time to access functionalized quaternary allylic amino acid derivatives (17 examples, up to 89% yield and 80% ee). Moreover, the broad scope and easy transformations of the products reinforce the value of this approach, which can enrich the chemistry of quaternary allylic amino acid derivatives.
中文翻译：
钯催化烯丙内酯与乙烯基氮丙啶的烯丙基烷基化反应构建季烯丙基氨基酸衍生物
首次实现了吖内酯与乙烯基氮丙啶的高效 Pd 催化烯丙基烷基化反应，以获得官能化的季烯丙基氨基酸衍生物（17 个例子，高达 89% 的产率和 80% ee）。此外，产品的广泛范围和易于转化增强了该方法的价值，可以丰富季烯丙基氨基酸衍生物的化学性质。
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