In this paper, axial 1,3-bis[4-(4-acetylpiperazin-1-yl)phenoxy]propanoxy and {2-[4-(4-acetylpiperazin-1-yl)phenoxy]ethoxy}ethoxy groups substituted silicon(IV) phthalocyanines (PP-D-Si, PP-OH2-Si) and their quaternized derivatives (PP-D-SiQ, PP-OH2-SiQ) were synthesized and characterized. The acetylcholinesterase inhibition values of 1,3-bis[4-(4-acetylpiperazin-1-yl)phenoxy]propanoxy and {2-[4-(4-acetylpiperazin-1-yl)phenoxy]ethoxy}ethoxy groups substituted silicon(IV) phthalocyanines (PP-D-Si, PP-OH2-Si) and their quaternized derivatives (PP-D-SiQ, PP-OH2-SiQ) were measured by IC₅₀ that reduces enzyme activity to 50% refers to the concentration of inhibitor. The synthesis compounds were classified as silicon and their quaternized derivatives and tagged as PP-D-Si, PP-OH2-Si, PP-D-SiQ and PP-OH2-SiQ. Except for the result of PP-D-SiQ was 1.586 ± 0.129 µM, the results were expressed as mM ranged between 0.553 and 3.626 mM.

本文采用轴向1,3-双[4-(4-乙酰哌嗪-1-基)苯氧基]丙氧基和{2-[4-(4-乙酰哌嗪-1-基)苯氧基]乙氧基}乙氧基取代硅( IV)合成并表征了酞菁( PP-D-Si、PP-OH2-Si )及其季铵化衍生物( PP-D-SiQ、PP-OH2-SiQ )。1,3-双[4-(4-乙酰哌嗪-1-基)苯氧基]丙氧基和{2-[4-(4-乙酰哌嗪-1-基)苯氧基]乙氧基}乙氧基取代硅( IV) 酞菁（PP-D-Si、PP-OH2-Si）及其季铵化衍生物（PP-D-SiQ、PP-OH2-SiQ）通过IC _50测量将酶活性降低到 50% 是指抑制剂的浓度。合成化合物分类为硅及其季铵化衍生物，并标记为PP-D-Si、PP-OH2-Si、PP-D-SiQ和PP-OH2-SiQ。除了PP-D-SiQ的结果为 1.586 ± 0.129 µM 外，结果以 mM 表示，范围在 0.553 和 3.626 mM 之间。