Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Ultrasensitive Chemiresistive Gas Sensor Can Diagnose Asthma and Monitor Its Severity by Analyzing Its Biomarker H2S: An Experimental, Clinical, and Theoretical Study
ACS Sensors ( IF 8.2 ) Pub Date : 2022-07-22 , DOI: 10.1021/acssensors.2c00737 Qiang Jing 1, 2 , Chengyi Gong 1 , Wengang Bian 3 , Qingyin Tian 1 , Yucai Zhang 3 , Ning Chen 4 , Caixue Xu 1 , Na Sun 3 , Xin Wang 1 , Chunjie Li 1 , Hongrui Dou 3 , Yunzhu An 4 , Shasha Liu 5 , Jiangying Yu 5 , Lipeng Wang 6 , Ping Li 5 , Shasha Han 6 , Dong Qian 2 , Bo Liu 1
ACS Sensors ( IF 8.2 ) Pub Date : 2022-07-22 , DOI: 10.1021/acssensors.2c00737 Qiang Jing 1, 2 , Chengyi Gong 1 , Wengang Bian 3 , Qingyin Tian 1 , Yucai Zhang 3 , Ning Chen 4 , Caixue Xu 1 , Na Sun 3 , Xin Wang 1 , Chunjie Li 1 , Hongrui Dou 3 , Yunzhu An 4 , Shasha Liu 5 , Jiangying Yu 5 , Lipeng Wang 6 , Ping Li 5 , Shasha Han 6 , Dong Qian 2 , Bo Liu 1
Affiliation
|
Asthma is a chronic disease characterized by recurrent attacks of breathlessness and wheezing, which vary in severity and frequency from person to person. H2S is considered as the biomarker of asthma. Here, an ultrasensitive chemiresistive H2S gas sensor based on a γ-Bi2MoO6–CuO heterostructure with a detection limit of 5 ppb has been fabricated. It can distinguish asthmatic patients from healthy people roughly by analyzing the exhaled breaths of 28 asthmatic patients and 28 healthy people, suggesting that the sensor can be used to assist physicians in the diagnosis of asthma. Pathologically, it is discovered by this sensor that with the relief of asthma, the concentration of H2S in one’s exhaled breath gradually increases. This subtle concentration variation of H2S can be accurately detected, indicating that this sensor can be used in the asthma severity monitoring too. Physical models have been built by first-principles calculation to reveal the causes of the sensor’s ultrasensitivity. The stable adsorption of H2S on the surface of CuO results in massive charge transferring and the appearance of the defect states, which play the major role in the ultrasensitivity of the sensor. Upon integrating this sensor with circuits, the cheap, smart, and portable H2S sensing device can be obtained, which can make asthmatic patients’ access to this device easy and make the severity monitoring of asthma convenient, especially for children and the aged.
中文翻译：
超灵敏化学电阻气体传感器可以通过分析其生物标志物 H2S 来诊断哮喘并监测其严重程度：一项实验、临床和理论研究
哮喘是一种慢性疾病，其特征是呼吸困难和喘息反复发作，其严重程度和频率因人而异。H 2 S被认为是哮喘的生物标志物。在这里，已经制造了一种基于 γ-Bi 2 MoO 6 –CuO 异质结构的超灵敏化学电阻 H 2 S 气体传感器，检测限为 5 ppb。通过对28名哮喘患者和28名健康人的呼气进行分析，可以大致区分哮喘患者和健康人，表明该传感器可用于辅助医生诊断哮喘。在病理上，该传感器发现随着哮喘的缓解，H 2的浓度呼气中的 S 逐渐增加。可以准确检测到这种细微的H 2 S浓度变化，表明该传感器也可用于哮喘严重程度监测。通过第一性原理计算建立了物理模型，以揭示传感器超灵敏度的原因。H 2 S在CuO表面的稳定吸附导致大量电荷转移和缺陷态的出现，这对传感器的超灵敏性起着重要作用。将此传感器与电路集成后，廉价、智能且便携的 H 2可以获得S传感装置，可以使哮喘患者更容易接触到该装置，方便哮喘严重程度的监测，尤其是对于儿童和老年人。
更新日期：2022-07-22
中文翻译：
超灵敏化学电阻气体传感器可以通过分析其生物标志物 H2S 来诊断哮喘并监测其严重程度：一项实验、临床和理论研究
哮喘是一种慢性疾病，其特征是呼吸困难和喘息反复发作，其严重程度和频率因人而异。H 2 S被认为是哮喘的生物标志物。在这里，已经制造了一种基于 γ-Bi 2 MoO 6 –CuO 异质结构的超灵敏化学电阻 H 2 S 气体传感器，检测限为 5 ppb。通过对28名哮喘患者和28名健康人的呼气进行分析，可以大致区分哮喘患者和健康人，表明该传感器可用于辅助医生诊断哮喘。在病理上，该传感器发现随着哮喘的缓解，H 2的浓度呼气中的 S 逐渐增加。可以准确检测到这种细微的H 2 S浓度变化，表明该传感器也可用于哮喘严重程度监测。通过第一性原理计算建立了物理模型，以揭示传感器超灵敏度的原因。H 2 S在CuO表面的稳定吸附导致大量电荷转移和缺陷态的出现，这对传感器的超灵敏性起着重要作用。将此传感器与电路集成后，廉价、智能且便携的 H 2可以获得S传感装置，可以使哮喘患者更容易接触到该装置，方便哮喘严重程度的监测，尤其是对于儿童和老年人。
京公网安备 11010802027423号