The regulatory role of N6-methyladenosine modification in the interaction between host and microbes,WIREs RNA

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The regulatory role of N6-methyladenosine modification in the interaction between host and microbes
WIREs RNA ( IF 6.4 ) Pub Date : 2022-03-17 , DOI: 10.1002/wrna.1725
Ruhao Zhuo ₁ , Menghui Xu ₁ , Xiaoyun Wang ₂ , Bin Zhou ₃ , Xin Wu ₄ , Vanessa Leone _{5,

6} , Eugene B. Chang ₆ , Xiang Zhong ₁

Affiliation

N⁶-methyladenosine (m⁶A) is the most prevalent posttranscriptional modification in eukaryotic mRNAs. Dynamic and reversible m⁶A modification regulates gene expression to control cellular processes and diverse biological functions. Growing evidence indicated that m⁶A modification is involved in the homeostasis of host and microbes (mostly viruses and bacteria). Disturbance of m⁶A modification affects the life cycles of viruses and bacteria, however, these microbes could in turn change host m⁶A modification leading to human disease including autoimmune diseases and cancer. Thus, we raise the concept that m⁶A could be a “messenger” molecule to participate in the interactions between host and microbes. In this review, we summarize the regulatory mechanisms of m⁶A modification on viruses and commensal microbiota, highlight the roles of m⁶A methylation in the interaction of host and microbes, and finally discuss drugs development targeting m⁶A modification.

中文翻译：

N6-甲基腺苷修饰在宿主与微生物相互作用中的调控作用

N ⁶ -甲基腺苷 (m ⁶ A) 是真核生物 mRNA 中最普遍的转录后修饰。动态和可逆的 m ⁶ A 修饰调节基因表达以控制细胞过程和多种生物学功能。越来越多的证据表明，m ⁶ A 修饰与宿主和微生物（主要是病毒和细菌）的稳态有关。m ⁶ A 修饰的干扰会影响病毒和细菌的生命周期，然而，这些微生物可能反过来改变宿主 m ⁶ A 修饰，导致人类疾病，包括自身免疫性疾病和癌症。因此，我们提出了 m ^6的概念A 可能是参与宿主和微生物之间相互作用的“信使”分子。在这篇综述中，我们总结了m ⁶ A 修饰对病毒和共生微生物群的调控机制，突出了m ⁶ A 甲基化在宿主和微生物相互作用中的作用，最后讨论了针对m ⁶ A 修饰的药物开发。

更新日期：2022-03-17

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