Bone and joint infections (BJI) are one of the most difficult-to-treat bacterial infection, especially in the era of antimicrobial resistance. Lytic bacteriophages (phages for short) are natural viruses that can selectively target and kill bacteria. They are considered to have a high therapeutic potential for the treatment of severe bacterial infections and especially BJI, as they also target biofilms. Here we report on the management of a patient with a pandrug-resistant Pseudomonas aeruginosa spinal abscess who was treated with surgery and a personalized combination of phage therapy that was added to antibiotics. As the infecting P. aeruginosa strain was resistant to the phages developed by private companies that were contacted, we set up a unique European academic collaboration to find, produce and administer a personalized phage cocktail to the patient in due time. After two surgeries, despite bacterial persistence with expression of small colony variants, the patient healed with local and intravenous injections of purified phages as adjuvant therapy.

骨和关节感染 (BJI) 是最难治疗的细菌感染之一，尤其是在抗菌素耐药性时代。溶菌噬菌体（简称噬菌体）是天然病毒，可以选择性地靶向和杀死细菌。它们被认为对治疗严重的细菌感染，尤其是 BJI 具有很高的治疗潜力，因为它们还靶向生物膜。在这里，我们报告了一名患有泛耐药铜绿假单胞菌脊柱脓肿的患者的治疗，该患者接受了手术治疗和添加到抗生素中的噬菌体治疗的个性化组合。作为感染性绿脓杆菌由于菌株对所接触的私营公司开发的噬菌体具有抗性，我们建立了一个独特的欧洲学术合作机构，以便在适当的时候为患者寻找、生产和管理个性化的噬菌体鸡尾酒。两次手术后，尽管细菌持续存在并表达小菌落变异，但患者通过局部和静脉注射纯化的噬菌体作为辅助治疗痊愈。