Fungi from the genus Thelephora have been exploited to identify bioactive compounds. The main natural products characterized are para-terphenyl derivatives, chiefly represented by the lead anti-inflammatory compound vialinin A isolated from species T. vialis and T. terrestris. Different series of p-terphenyls have been identified, including vialinins, ganbajunins, terrestrins, telephantins and other products. Their mechanism of action is not always clearly identified, and different potential molecule targets have been proposed. The lead vialinin A functions as a protease inhibitor, efficiently targeting ubiquitin-specific peptidases USP4/5 and sentrin-specific protease SENP1 which are prominent anti-inflammatory and anticancer targets. Protease inhibition is coupled with a powerful inhibition of the cellular production of tumor necrosis factor TNFα. Other mechanisms contributing to the anti-inflammatory or anti-proliferative action of these p-terphenyl compounds have been invoked, including the formation of cytotoxic copper complexes for derivatives bearing a catechol central unit such vialinin A, terrestrin B and telephantin O. These p-terphenyl compounds could be further exploited to design novel anticancer agents, as evidenced with the parent compound terphenyllin (essentially found in Aspergillus species) which has revealed marked antitumor and anti-metastatic effects in xenograft models of gastric and pancreatic cancer. This review shed light on the structural and functional diversity of p-terphenyls compounds isolated from Thelephora species, their molecular targets and pharmacological properties.

来自Thelephora属的真菌已被用于鉴定生物活性化合物。表征的主要天然产物是对-三联苯衍生物，主要代表是从物种T. vialis和T. terrestris中分离出来的先导抗炎化合物 vialinin A。不同系列的p-三联苯已被鉴定，包括vialinins、ganbajunins、terrestrins、telephantins和其他产品。它们的作用机制并不总是清楚地确定，并且已经提出了不同的潜在分子靶标。前导 vialinin A 作为蛋白酶抑制剂发挥作用，有效靶向泛素特异性肽酶 USP4/5 和哨兵特异性蛋白酶 SENP1，它们是重要的抗炎和抗癌靶点。蛋白酶抑制与对肿瘤坏死因子 TNFα 细胞产生的强大抑制相结合。其他有助于这些p的抗炎或抗增殖作用的机制-三联苯化合物已被调用，包括为带有儿茶酚中心单元的衍生物形成细胞毒性铜络合物，如vialinin A、terrestrin B和telephantin O。这些对三联苯化合物可进一步用于设计新型抗癌剂，如母体化合物三联苯胺（主要存在于曲霉属中）在胃癌和胰腺癌的异种移植模型中显示出显着的抗肿瘤和抗转移作用。本综述阐明了从Thelephora物种中分离的对三联苯化合物的结构和功能多样性、它们的分子靶点和药理特性。