核仁素的细胞定位决定癌症的预后：荟萃分析,Journal of Molecular Medicine

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核仁素的细胞定位决定癌症的预后：荟萃分析
Journal of Molecular Medicine ( IF 4.8 ) Pub Date : 2022-07-21 , DOI: 10.1007/s00109-022-02228-w
Supaporn Yangngam ₁ , Jaturawitt Prasopsiri ₁ , Phimmada Hatthakarnkul _{2,

3} , Suyanee Thongchot _{1,

4} , Peti Thuwajit ₁ , Pa-Thai Yenchitsomanus ₄ , Joanne Edwards ₃ , Chanitra Thuwajit ₁

Affiliation

核仁素 (NCL) 是一种在细胞核、细胞质和细胞膜中表达的多功能蛋白质。NCL 的过表达作为癌症预后不良的标志物具有争议性。在这项研究中，进行了一项荟萃分析，以评估 NCL 在一系列癌症的不同亚细胞定位（细胞质 (CyNCL) 和细胞核 (NuNCL)）中的预后价值。搜索了 PubMed 以查找相关出版物。从涉及 1221 名患有 8 种癌症类型的患者的 12 项研究中提取和分析数据。结果显示，高总 NCL 与较差的总生存期 (OS) (HR = 2.85 (1.94, 4.91), p < 0.00001, I ² = 59%) 和较短的无病生存期 (DFS) (HR = 3.57 (HR = 3.57)显着相关。 2.76, 4.62), p < 0.00001,I ² = 2%）。高 CyNCL 与较差的 OS (HR = 4.32 (3.01, 6.19), p < 0.00001, I ² = 0%) 和短 DFS (HR = 3.00 (2.17, 4.15), p < 0.00001, I ² = 0% ) 显着相关）。相反，高 NuNCL 与患者 OS 增加相关（HR = 0.42 (0.20, 0.86), p = 0.02, I ² = 66%），与观察到的 DFS 无显着相关性（HR = 0.46 (0.19, 1.14), p = 0.09，I ² = 57%）。该研究支持亚细胞 NCL 作为预后不良的癌症生物标志物的作用。

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Cellular localization of nucleolin determines the prognosis in cancers: a meta-analysis

Nucleolin (NCL) is a multifunctional protein expressed in the nucleus, cytoplasm, and cell membrane. Overexpression of NCL has a controversial role as a poor prognostic marker in cancers. In this study, a meta-analysis was performed to evaluate the prognostic value of NCL in different subcellular localizations (cytoplasmic (CyNCL) and nuclear (NuNCL)) across a range of cancers. PubMed was searched for relevant publications. Data were extracted and analyzed from 12 studies involving 1221 patients with eight cancer types. The results revealed high total NCL was significantly associated with poor overall survival (OS) (HR = 2.85 (1.94, 4.91), p < 0.00001, I² = 59%) and short disease-free survival (DFS) (HR = 3.57 (2.76, 4.62), p < 0.00001, I² = 2%). High CyNCL was significantly associated with poor OS (HR = 4.32 (3.01, 6.19), p < 0.00001, I² = 0%) and short DFS (HR = 3.00 (2.17, 4.15), p < 0.00001, I² = 0%). In contrast, high NuNCL correlated with increased patient OS (HR = 0.42 (0.20, 0.86), p = 0.02, I² = 66%), with no significant correlation to DFS observed (HR = 0.46 (0.19, 1.14), p = 0.09, I² = 57%). This study supports the role of subcellular NCL as a poor prognostic cancer biomarker.

更新日期：2022-07-21

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