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Direct synthesis of trifluoroethylated benzofurans from silver-catalyzed annulation of trifluoromethyl propynols with phenols
Tetrahedron ( IF 2.1 ) Pub Date : 2022-07-19 , DOI: 10.1016/j.tet.2022.132929
Bo-Lun Hu , Chao-Fei Wu , Xing-Guo Zhang , Jimin Kim

An efficient method for the synthesis of trifluoroethylated benzofurans from trifluoromethyl propynols with general phenols was developed. In the presence of AgNTf2, a variety of trifluoromethyl propynols underwent cascade Friedel-Crafts propargylation/Michael-type addition/1,3-H shift reactions with various phenols successfully to afford the corresponding trifluoroethylated benzofuran in moderate to good yields.



中文翻译:

银催化三氟甲基丙炔醇与苯酚环化直接合成三氟乙基化苯并呋喃

开发了一种由三氟甲基丙炔醇与一般酚类合成三氟乙基化苯并呋喃的有效方法。在AgNTf 2存在下,多种三氟甲基丙炔醇与各种酚类发生级联Friedel-Crafts炔丙基化/迈克尔型加成/1,3-H变换反应,以中等至良好的收率成功地得到相应的三氟乙基化苯并呋喃。

更新日期:2022-07-19
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