A practical method that employs TMSCF₂Br as a dual C₁ synthon for the synthesis of a series of difluoromethylated formimidamides from primary aryl amines via a fluoromethylimine intermediate is described. The tolerance of the method to important functional groups including esters, alkynes, and difluoromethyl groups is explored. Gram-scale reactions are also included.

中文翻译：

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使用 TMSCF2Br 作为双 C1 合成子从芳基伯胺合成二氟甲基化甲酰亚胺酰胺

描述了一种使用 TMSCF ₂ Br 作为双 C ₁合成子的实用方法，用于从芳基伯胺通过氟甲基亚胺中间体合成一系列二氟甲基化甲酰亚胺酰胺。探讨了该方法对重要官能团（包括酯、炔烃和二氟甲基）的耐受性。还包括克级反应。