当前位置:
X-MOL 学术
›
Org. Lett.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Bioorthogonal Cleavage of Tetrazine-Caged Ethers and Esters Triggered by trans-Cyclooctene
Organic Letters ( IF 4.9 ) Pub Date : 2022-07-17 , DOI: 10.1021/acs.orglett.2c01873
Yayue Wang 1 , Guohua Shen 2 , Jie Li 1 , Wuyu Mao 1 , Hongbao Sun 1 , Ping Feng 3 , Haoxing Wu 1
Organic Letters ( IF 4.9 ) Pub Date : 2022-07-17 , DOI: 10.1021/acs.orglett.2c01873
Yayue Wang 1 , Guohua Shen 2 , Jie Li 1 , Wuyu Mao 1 , Hongbao Sun 1 , Ping Feng 3 , Haoxing Wu 1
Affiliation
![]() |
In this study, we report the bioorthogonal cleavage of physiologically stable methylene tetrazines bearing an ether or ester linkage in the presence of trans-cyclooctene. Based on this approach, molecules with phenol or carboxylic acid moieties were efficiently released in a controlled manner, which can be effectively applied in living cells. We expect this bioorthogonal cleavage approach can be applied to several biomedical applications, including the development of antibody–drug conjugates, pretargeted prodrug release, and protein activation.
中文翻译:
由反式环辛烯引发的四嗪笼状醚和酯的生物正交裂解
在这项研究中,我们报告了在反式-环辛烯存在下具有醚或酯键的生理稳定的亚甲基四嗪的生物正交裂解。基于这种方法,具有苯酚或羧酸部分的分子以受控方式有效释放,可有效应用于活细胞。我们预计这种生物正交切割方法可以应用于多种生物医学应用,包括抗体-药物偶联物的开发、预靶向前药释放和蛋白质活化。
更新日期:2022-07-17
中文翻译:

由反式环辛烯引发的四嗪笼状醚和酯的生物正交裂解
在这项研究中,我们报告了在反式-环辛烯存在下具有醚或酯键的生理稳定的亚甲基四嗪的生物正交裂解。基于这种方法,具有苯酚或羧酸部分的分子以受控方式有效释放,可有效应用于活细胞。我们预计这种生物正交切割方法可以应用于多种生物医学应用,包括抗体-药物偶联物的开发、预靶向前药释放和蛋白质活化。