The off-target payload delivery of γ-cyclodextrin metal organic framework (γ-CD-MOF) does not meet the requirements for targeted drug delivery applications. Herein, we synthesized γ-CD-MOF and crosslinked γ-CD-MOF (CL-γ-CD-MOF) to obtain the different sizes and different types of γ-CD-MOF. Furthermore, a simple post-modification method was applied to obtain the biofunctionalized γ-CD-MOFs to improve cellular interaction through hyaluronic acid (HA) for the first time. Various methods including measurement of different size of γ-CD-MOF, CL-γ-CD-MOF, and surface modified γ-CD-MOFs, followed by the characterization by various analytical techniques, drug absorption, cell viability, and cellular uptake studies, were performed to determine the functionality of the studied γ-CD-MOF-HA systems. The conjugation of γ-CD-MOF with HA (γ-CD-MOF-HA) showed a 4.8% higher average drug loading capacity than the γ-CD-MOF. It was found that the γ-CD-MOF-HA showed pH-responsive drug release and enhanced the cellular uptake of Doxorubicin (Dox) in HeLa cells. The present study results indicate the efficacy of the γ-CD-MOF-HA as a nano carrier, enabling a new direction for γ-CD-MOF to target the different tissues and cells.

γ-环糊精金属有机骨架（γ-CD-MOF）的脱靶有效载荷递送不符合靶向药物递送应用的要求。在此，我们合成了γ-CD-MOF和交联的γ-CD-MOF（CL-γ-CD-MOF）以获得不同尺寸和不同类型的γ-CD-MOF。此外，首次应用简单的后修饰方法获得生物功能化的γ-CD-MOFs，以通过透明质酸（HA）改善细胞相互作用。各种方法，包括测量不同尺寸的 γ-CD-MOF、CL-γ-CD-MOF 和表面改性的 γ-CD-MOF，然后通过各种分析技术、药物吸收、细胞活力和细胞摄取研究进行表征，进行以确定所研究的 γ-CD-MOF-HA 系统的功能。γ-CD-MOF 与 HA (γ-CD-MOF-HA) 的共轭显示为 4。平均载药量比 γ-CD-MOF 高 8%。发现 γ-CD-MOF-HA 表现出 pH 响应性药物释放，并增强了 HeLa 细胞中阿霉素 (Dox) 的细胞摄取。本研究结果表明γ-CD-MOF-HA作为纳米载体的功效，为γ-CD-MOF靶向不同组织和细胞提供了新的方向。