<br>通过 AI 控制的微流控 ELISA 设备使用唾液进行 COVID-19 检测的疾病互联网系统,Advanced Materials Technologies

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通过 AI 控制的微流控 ELISA 设备使用唾液进行 COVID-19 检测的疾病互联网系统
Advanced Materials Technologies ( IF 6.4 ) Pub Date : 2022-07-15 , DOI: 10.1002/admt.202101690
Nabil Hossain Bhuiyan ₁ , Md Jalal Uddin _{1,

2} , Joowon Lee ₁ , Jun Hyeok Hong ₁ , Joon Sub Shim _{1,

2}

Affiliation

在冠状病毒病 (COVID-19) 爆发期间，一个国家的疾病控制和预防中心 (CDCP) 需要对特定地区进行监测，以提供公共卫生指导。在这项工作中，建议使用疾病互联网（IoD）对传染病进行持续实时监测，以促进公共卫生。由于将信息和通信技术 (ICT) 与定点护理 (POC) 设备相融合，使 IoD 能够持续实时健康监测和处理临床记录至关重要，因此需要一个与芯片实验室相关联的 IoD 平台已开发出用于从口咽唾液样本诊断严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的（LOC）设备，并将结果诊断数据上传到基于云的系统中，以与CDCP连接。此外，还提出了用于可视化省级感染率的等值区域 IoD 地图以及 IoD 平台。所开发的平台应用于LOD低至0.013 ng mL ^-1的SARS-CoV-2 N蛋白抗原的定量，并成功利用IoD图预测了各省份的感染率。因此，拟议的 IoD 系统有可能成为疾病控制和预防中心通过识别特定地区的严重程度来抑制 COVID-19 爆发的必要工具。

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An Internet-of-Disease System for COVID-19 Testing Using Saliva by an AI-Controlled Microfluidic ELISA Device

Throughout coronavirus disease (COVID-19) outbreaks, the centers for disease control and prevention (CDCP) of a country require monitoring of particular territories to provide public health guidance. In this work, the Internet of Diseases (IoD) is suggested for continuous real-time monitoring of infectious diseases for public health. Because converging information and communication technologies (ICTs) with point-of-care (POC) devices to enable the IoD for continuous real-time health monitoring and processing of clinical records are crucial, an IoD platform associating a lab-on-a-chip (LOC) device to diagnose severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) from oropharyngeal saliva samples have been developed and uploaded the resulted diagnostic data into a cloud-based system to be connected with CDCP. Moreover, a choropleth IoD map to visualize provincial infection rate is proposed along with the IoD platform. The developed platform is applied for the quantification of SARS-CoV-2 N-protein antigen with a LOD as low as 0.013 ng mL⁻¹ and the infection rate of various provinces is projected with the IoD map successfully. Thus, the proposed IoD system has the potential to become an imperative tool for the disease control and prevention centers to restrain COVID-19 outbreaks by identifying the severity of particular regions.

更新日期：2022-07-15

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