当前位置:
X-MOL 学术
›
Angew. Chem. Int. Ed.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
H2O2-Responsive NIR-II AIE Nanobomb for Carbon Monoxide Boosting Low-Temperature Photothermal Therapy
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2022-07-15 , DOI: 10.1002/anie.202207213
Gongcheng Ma 1, 2 , Zhongke Liu 1, 3 , Chunguang Zhu 4 , Huajie Chen 4 , Ryan T K Kwok 5 , Pengfei Zhang 1, 2 , Ben Zhong Tang 6 , Lintao Cai 1, 2 , Ping Gong 1, 2
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2022-07-15 , DOI: 10.1002/anie.202207213
Gongcheng Ma 1, 2 , Zhongke Liu 1, 3 , Chunguang Zhu 4 , Huajie Chen 4 , Ryan T K Kwok 5 , Pengfei Zhang 1, 2 , Ben Zhong Tang 6 , Lintao Cai 1, 2 , Ping Gong 1, 2
Affiliation
![]() |
The upregulated expression of heat shock proteins (HSPs) impairs the therapeutic efficacy of photothermal therapy (PTT). Inhibition of HSPs repair is crucial for improving the efficiency of low-temperature PTT. The AIE nanobomb PBPTV@mPEG(CO) could be triggered by the over-expressed hydrogen peroxide in the tumor microenvironment and release CO to inhibit the upregulated expression of HSPs during low-temperature PTT to enhance the antitumor efficiency.
中文翻译:
用于一氧化碳促进低温光热治疗的 H2O2 响应 NIR-II AIE 纳米弹
热休克蛋白 (HSPs) 的上调表达削弱了光热疗法 (PTT) 的治疗效果。抑制 HSPs 修复对于提高低温 PTT 的效率至关重要。AIE纳米弹PBPTV@mPEG(CO)可以由肿瘤微环境中过表达的过氧化氢触发并释放CO来抑制低温PTT过程中HSPs的上调表达,从而提高抗肿瘤效率。
更新日期:2022-07-15
中文翻译:

用于一氧化碳促进低温光热治疗的 H2O2 响应 NIR-II AIE 纳米弹
热休克蛋白 (HSPs) 的上调表达削弱了光热疗法 (PTT) 的治疗效果。抑制 HSPs 修复对于提高低温 PTT 的效率至关重要。AIE纳米弹PBPTV@mPEG(CO)可以由肿瘤微环境中过表达的过氧化氢触发并释放CO来抑制低温PTT过程中HSPs的上调表达,从而提高抗肿瘤效率。