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Novel marker for predicting the severity and prognosis of acute pulmonary embolism: platelet-to-hemoglobin ratio
Biomarkers in Medicine ( IF 1.9 ) Pub Date : 2022-07-14 , DOI: 10.2217/bmm-2022-0201
Nail B Ozbeyaz 1 , Gokhan Gokalp 1 , Adil E Gezer 2 , Engin Algul 3 , Haluk F Sahan 3 , Faruk Aydinyilmaz 4 , Ilkin Guliyev 5 , Kamuran Kalkan 3
Affiliation  

Background: We investigated the ability of the platelet-to-hemoglobin ratio (PHR) to predict mortality and disease severity in patients with acute pulmonary embolism (APE). Materials & methods: The severity of APE was classified as massive (high risk), submassive (intermediate risk) or nonmassive (low risk). PHR is defined as platelet count/hemoglobin count. Results: PHR was significantly higher in patients with massive APE, and this elevation showed a gradual increase from the nonmassive group to the massive group (p < 0.001). In-hospital and 1-month mortality were higher in patients with high PHR values. PHR was an independent risk factor for the development of massive APE (odds ratio: 1.014; 95% CI: 1.011–1.017; p = 0.009). Conclusion: PHR values predicted massive APE and were an independent predictor of mortality in APE.



中文翻译:

预测急性肺栓塞严重程度和预后的新标志物:血小板与血红蛋白的比值

背景:我们调查了血小板与血红蛋白比率 (PHR) 预测急性肺栓塞 (APE) 患者死亡率和疾病严重程度的能力。材料与方法: APE 的严重程度分为大规模(高风险)、次大规模(中等风险)或非大规模(低风险)。PHR 定义为血小板计数/血红蛋白计数。结果:大块 APE 患者的 PHR 显着升高,并且这种升高显示出从非大块组到大块组的逐渐增加(p < 0.001)。PHR 值高的患者住院和 1 个月死亡率较高。PHR 是发生大规模 APE 的独立危险因素(优势比:1.014;95% CI:1.011-1.017;p = 0.009)。结论:PHR 值预测大量 APE,并且是 APE 死亡率的独立预测因子。

更新日期:2022-07-15
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