Sakuranetin (SKN), a naturally derived 7-O-methylated flavonoid, was first identified in the bark of the cherry tree (Prunus spp.) as an aglycone of sakuranin and then purified from the bark of Prunus puddum. It was later reported in many other plants including Artemisia campestris, Boesenbergia pandurata, Baccharis spp., Betula spp., Juglans spp., and Rhus spp. In plants, it functions as a phytoalexin synthesized from its precursor naringenin and is the only known phenolic phytoalexin in rice, which is released in response to different abiotic and biotic stresses such as UV-irradiation, jasmonic acid, cupric chloride, L-methionine, and the phytotoxin coronatine. Till date, SKN has been widely reported for its diverse pharmacological benefits including antioxidant, anti-inflammatory, antimycobacterial, antiviral, antifungal, antileishmanial, antitrypanosomal, glucose uptake stimulation, neuroprotective, antimelanogenic, and antitumor properties. Its pharmacokinetics and toxicological properties have been poorly understood, thus warranting further evaluation together with exploring other pharmacological properties such as antidiabetic, neuroprotective, and antinociceptive effects. Besides, in vivo studies or clinical investigations can be done for proving its effects as antioxidant and anti-inflammatory, antimelanogenic, and antitumor agent. This review summarizes all the reported investigations with SKN for its health-beneficial roles and can be used as a guideline for future studies.

中文翻译：

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Sakuranetin 及其治疗潜力——全面回顾

Sakuranetin (SKN)，一种天然衍生的 7-欧-甲基化类黄酮，首先在樱桃树的树皮中被发现（普鲁努s spp.) 作为 sakuranin 的糖苷配基，然后从红枣. 后来在许多其他工厂中也有报道，包括油菜,蒲公英,酒神种，桦木属种，核桃属种，和漆树属属 在植物中，它作为一种由其前体柚皮素合成的植物抗毒素发挥作用，是水稻中唯一已知的酚类植物抗毒素，可响应不同的非生物和生物胁迫而释放，例如紫外线照射、茉莉酸、氯化铜、L-甲硫氨酸、和植物毒素冠状素。迄今为止，SKN 因其多种药理学益处而被广泛报道，包括抗氧化、抗炎、抗分枝杆菌、抗病毒、抗真菌、抗利什曼原虫、抗锥虫、葡萄糖摄取刺激、神经保护、抗黑色素生成和抗肿瘤特性。其药代动力学和毒理学特性知之甚少，因此需要进一步评估，同时探索其他药理特性，如抗糖尿病、神经保护和镇痛作用。除了，体内可以进行研究或临床调查，以证明其作为抗氧化和抗炎、抗黑色素生成和抗肿瘤剂的作用。这篇综述总结了所有关于 SKN 对健康有益作用的调查报告，可作为未来研究的指南。