用于心脏组织工程的导电和半导电纳米复合水凝胶,Advanced Healthcare Materials

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用于心脏组织工程的导电和半导电纳米复合水凝胶
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2022-07-13 , DOI: 10.1002/adhm.202200526
Sania Ghobadi Alamdari _{1,

2} , Abbas Alibakhshi ₃ , Miguel de la Guardia ₄ , Behzad Baradaran ₂ , Reza Mohammadzadeh ₁ , Mohammad Amini ₂ , Prashant Kesharwani ₅ , Ahad Mokhtarzadeh ₂ , Fatemeh Oroojalian _{6,

7} , Amirhossein Sahebkar _{8,

9,

10}

Affiliation

Department of Cell and Molecular Biology, Faculty of Basic Science, University of Maragheh, Maragheh, 83111-55181, Iran.
Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, 5165665931, Iran.
Molecular Medicine Research Center, Hamadan University of Medical Sciences, Hamadan, 6517838736, Iran.
Department of Analytical Chemistry, University of Valencia, Dr. Moliner 50, Burjassot, Valencia, 46100, Spain.
Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, 110062, India.
Department of Advanced Technologies, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, 94149-75516, Iran.
Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, 94149-75516, Iran.
Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, 9177899191, Iran.
Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, 9177899191, Iran.
Department of Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, 9177899191, Iran.

心血管疾病是全世界死亡的主要原因，最常见的原因是心肌梗塞。因此，应使用适当的方法来修复受损的心脏组织。最近，心脏组织工程方法已被广泛研究。自心血管组织工程的性质创立以来，细胞和支架技术取得了许多进展。由于水凝胶的水合和多孔结构，它们被用作支持基质以将细胞递送至梗塞组织。在心脏组织再生中，除了保护细胞外，还需要模拟天然组织微环境以支持心肌壁应力的生物活性和可生物降解的水凝胶。最近，纳米结构水凝胶的使用增加了纳米复合水凝胶的使用，并彻底改变了心脏组织工程领域。因此，为了克服水凝胶由于其机械脆性而导致的使用限制，各种聚合物、金属和碳的纳米颗粒被用于组织工程，并创造了提供具有优异性能的水凝胶的新机会。在此，简要介绍了用于心脏组织工程的合成和天然聚合物水凝胶、纳米碳基水凝胶和其他基于纳米颗粒的材料的类型，重点是导电纳米结构水凝胶。和碳用于组织工程，并创造了提供具有优异性能的水凝胶的新机会。在此，简要介绍了用于心脏组织工程的合成和天然聚合物水凝胶、纳米碳基水凝胶和其他基于纳米颗粒的材料的类型，重点是导电纳米结构水凝胶。和碳用于组织工程，并创造了提供具有优异性能的水凝胶的新机会。在此，简要介绍了用于心脏组织工程的合成和天然聚合物水凝胶、纳米碳基水凝胶和其他基于纳米颗粒的材料的类型，重点是导电纳米结构水凝胶。

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Conductive and Semiconductive Nanocomposite-Based Hydrogels for Cardiac Tissue Engineering

Cardiovascular disease is the leading cause of death worldwide and the most common cause is myocardial infarction. Therefore, appropriate approaches should be used to repair damaged heart tissue. Recently, cardiac tissue engineering approaches have been extensively studied. Since the creation of the nature of cardiovascular tissue engineering, many advances have been made in cellular and scaffolding technologies. Due to the hydrated and porous structures of the hydrogel, they are used as a support matrix to deliver cells to the infarct tissue. In heart tissue regeneration, bioactive and biodegradable hydrogels are required by simulating native tissue microenvironments to support myocardial wall stress in addition to preserving cells. Recently, the use of nanostructured hydrogels has increased the use of nanocomposite hydrogels and has revolutionized the field of cardiac tissue engineering. Therefore, to overcome the limitation of the use of hydrogels due to their mechanical fragility, various nanoparticles of polymers, metal, and carbon are used in tissue engineering and create a new opportunity to provide hydrogels with excellent properties. Here, the types of synthetic and natural polymer hydrogels, nanocarbon-based hydrogels, and other nanoparticle-based materials used for cardiac tissue engineering with emphasis on conductive nanostructured hydrogels are briefly introduced.

更新日期：2022-07-13

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