Synthesis of heterocyclic (triazole, furoxan, furazan) fused pyridazine di-N-oxides via hypervalent iodine oxidation,New Journal of Chemistry

当前位置： X-MOL 学术 › New J. Chem. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Synthesis of heterocyclic (triazole, furoxan, furazan) fused pyridazine di-N-oxides via hypervalent iodine oxidation
New Journal of Chemistry ( IF 2.7 ) Pub Date : 2022-07-12 , DOI: 10.1039/d2nj02908a
Qi Zhang _{1,

2} , Chunlin He _{1,

2,

3,

4,

5} , Siping Pang _{1,

3}

Affiliation

A novel approach for the synthesis of heterocyclic (triazole, furoxan, furazan) fused pyridazine di-N-oxides was described. The use of PIDA as a mild oxidant enabled the synthesis of these motifs in an efficient manner, which solved the issues of harsh conditions and cumbersome manipulation of existing methods. Moreover, the first synthesis of triazole fused pyridazine di-N-oxide provides a usable building block for the preparation of highly biologically relevant molecules as well as energetic compounds.

中文翻译：

通过高价碘氧化合成杂环（三唑，呋喃，呋喃）稠合哒嗪二-N-氧化物

描述了一种合成杂环（三唑、呋喃、呋喃）稠合哒嗪二-N-氧化物的新方法。PIDA作为温和氧化剂的使用能够以有效的方式合成这些基序，从而解决了现有方法条件苛刻和操作繁琐的问题。此外，三唑稠合哒嗪二-N-氧化物的首次合成为制备高度生物相关分子以及高能化合物提供了可用的构件。

更新日期：2022-07-12

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南