生物转化新进展——2021 年回顾,Drug Metabolism Reviews

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生物转化新进展——2021 年回顾
Drug Metabolism Reviews ( IF 3.4 ) Pub Date : 2022-08-30 , DOI: 10.1080/03602532.2022.2097253
S Cyrus Khojasteh ₁ , Upendra A Argikar ₂ , Sungjoon Cho ₁ , Rachel Crouch ₃ , Carley J S Heck ₄ , Kevin M Johnson ₁ , Amit S Kalgutkar ₅ , Lloyd King ₆ , Hlaing Holly Maw ₇ , Herana Kamal Seneviratne ₈ , Shuai Wang ₁ , Cong Wei ₉ , Donglu Zhang ₁ , Klarissa D Jackson ₁₀

Affiliation

Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc, South San Francisco, CA, USA.
Non-clinical Development, Bill and Melinda Gates Medical Research Institute, Cambridge, MA, USA.
Department of Pharmaceutical Sciences, Lipscomb University College of Pharmacy and Health Sciences, Nashville, TN, USA.
Medicine Design, Pfizer Worldwide Research, Development and Medical, Groton, CT, USA.
Medicine Design, Pfizer Worldwide Research, Development and Medical, Cambridge, MA, USA.
Quantitative Drug Discovery, UCB Biopharma UK, Slough, UK.
Drug Metabolism and Pharmacokinetics, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT, USA.
Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Drug Metabolism and Pharmacokinetics, Biogen Inc, Cambridge, MA, USA.
Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, Chapel Hill, NC, USA.

摘要

随着影响疗效和安全性的新分子结构和代谢途径的发现，生物转化领域不断发展。Kramlinger 等人最近的评论。( 2022 ) 很好地捕捉了具有高度影响力的生物转化科学的未来（和过去）（参见第一篇文章）。根据所选文章，这篇综述分为三个部分：(1) 新模式生物转化，(2) 药物发现生物转化，以及 (3) 药物开发生物转化 ().

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更新日期：2022-08-30

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