Liquid-Phase Peptide Synthesis (LPPS): A Third Wave for the Preparation of Peptides,Chemical Reviews

当前位置： X-MOL 学术 › Chem. Rev. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Liquid-Phase Peptide Synthesis (LPPS): A Third Wave for the Preparation of Peptides
Chemical Reviews ( IF 51.4 ) Pub Date : 2022-07-11 , DOI: 10.1021/acs.chemrev.2c00132
Anamika Sharma _{1,

2} , Ashish Kumar _{1,

3,

4} , Beatriz G de la Torre ₃ , Fernando Albericio _{1,

5,

6}

Affiliation

Since the last century, peptides have gained wide acceptance as drugs, with almost 100 already in the market and a large number in the pipeline. In this context, peptide synthesis has grown massively as a stringent field for pharmaceuticals around the globe. Three methodologies, namely, classical solution peptide synthesis (CSPS), solid-phase peptide synthesis (SPPS), and liquid-phase peptide synthesis (LPPS), have made significant contributions to the field. This review provides a comprehensive and integrated vision of LPPS as the third wave for peptide synthesis. LPPS combines the advantages of CSPS and SPPS, where peptide elongation is carried out in solution and the growing peptide chain is supported on a soluble tag, which confers characteristic properties. LPPS protocols allow the large-scale production of peptides and reduce the use of excess reagents and solvents, thus meeting the principles of green chemistry. In this review, tags associated with LPPS are broadly discussed under the following headings: polydisperse polyethylene glycol (PEG), membrane-enhanced peptide synthesis (MEPS), fluorous technology, ionic liquids (ILs), PolyCarbon, hydrophobic polymers, and group-assisted purification (GAP). It also highlights the signature accomplishments of LPPS tags and the limitations of the same.

中文翻译：

液相肽合成 (LPPS)：肽制备的第三波浪潮

自上个世纪以来，肽作为药物获得了广泛的认可，已有近 100 种药物投放市场，还有大量正在筹备中。在这种情况下，肽合成已成为全球制药业的一个严格领域。三种方法，即经典溶液肽合成（CSPS）、固相肽合成（SPPS）和液相肽合成（LPPS），对该领域做出了重大贡献。这篇综述提供了 LPPS 作为第三波肽合成浪潮的全面而综合的愿景。LPPS 结合了 CSPS 和 SPPS 的优点，其中肽延伸在溶液中进行，正在生长的肽链由可溶性标签支持，从而具有特征性。LPPS 协议允许大规模生产肽并减少过量试剂和溶剂的使用，从而符合绿色化学的原则。在这篇综述中，与 LPPS 相关的标签在以下标题下进行了广泛讨论：多分散聚乙二醇 (PEG)、膜增强肽合成 (MEPS)、氟技术、离子液体 (IL)、聚碳、疏水聚合物和基团辅助纯化（GAP）。它还强调了 LPPS 标签的签名成就及其局限性。疏水聚合物和基团辅助纯化（GAP）。它还强调了 LPPS 标签的签名成就及其局限性。疏水聚合物和基团辅助纯化（GAP）。它还强调了 LPPS 标签的签名成就及其局限性。

更新日期：2022-07-11

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南