Nature Communications ( IF 14.7 ) Pub Date : 2022-07-08 , DOI: 10.1038/s41467-022-31634-4 Hao Long 1, 2 , Tian-Sheng Chen 1 , Jinshuai Song 3 , Shaobin Zhu 4 , Hai-Chao Xu 1, 2
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The direct hydroxylation of arene C–H bonds is a highly sought-after transformation but remains an unsolved challenge due to the difficulty in efficient and regioselective C–H oxygenation and high reactivity of the phenolic products leading to overoxidation. Herein we report electrochemical C–H hydroxylation of arenes in continuous flow for the synthesis of phenols. The method is characterized by broad scope (compatible with arenes of diverse electronic properties), mild conditions without any catalysts or chemical oxidants, and excellent scalability as demonstrated by the continuous production of 1 mol (204 grams) of one of the phenol products.
中文翻译：
连续流中电化学芳族C-H羟基化
芳烃C-H键的直接羟基化是一种备受追捧的转化，但由于高效和区域选择性的C-H氧化困难以及酚类产物的高反应性导致过度氧化，因此仍然是一个尚未解决的挑战。在此，我们报道了芳烃在连续流动中的电化学 C-H 羟基化，用于合成酚类。该方法的特点是适用范围广（与多种电子性质的芳烃兼容）、条件温和、无需任何催化剂或化学氧化剂，并且具有优异的可扩展性，如连续生产1摩尔（204克）其中一种苯酚产品所证明的那样。
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