Two new chromeno[3,2-c]pyridine alkaloids, 9-acetyl-7-methoxy-3-methyl-10H-chromeno[3,2-c]pyridin- 10-one (1) and 8-acetyl-7-methoxy-3-methyl-10H-chromeno[3,2-c]pyridin-10-one (2), were isolated from the whole plants of Thalictrum scabrifolium. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1 and 2 were tested for their antibacterial activity. The results showed that both compounds showed high antibacterial activity against 12 microbial strains isolated from the saliva of smokers.

两种新的色烯[3,2-c]吡啶生物碱，9-acetyl-7-methoxy-3-methyl-10 H - chromeno[3,2-c]pyridin-10-one ( 1 ) 和 8-acetyl-7 -methoxy-3-methyl-10 H -chromeno[3,2-c]pyridin-10-one ( 2 )，从Thalictrum scabrifolium的全株中分离得到。它们的结构是通过 HR-ESI-MS 和广泛的 1D 和 2D NMR 光谱研究确定的。测试了化合物1和2的抗菌活性。结果表明，这两种化合物对从吸烟者唾液中分离出的 12 种微生物菌株均显示出高抗菌活性。