无粘合剂、可拉伸和可渗透的多重伤口护理平台,ACS Sensors

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无粘合剂、可拉伸和可渗透的多重伤口护理平台
ACS Sensors ( IF 8.2 ) Pub Date : 2022-07-07 , DOI: 10.1021/acssensors.2c00787
Matthew S Brown ₁ , Karen Browne _{2,

3} , Nancy Kirchner ₃ , Ahyeon Koh ₁

Affiliation

伤口愈合过程仍然是一个鲜为人知的生物学机制。与慢性伤口相关的高发病率和死亡率是医疗保健行业的一个关键问题。尽管存在评估和治疗方案，但这些策略主要依赖于不考虑动态物理化学微环境的静态伤口敷料，并且经常通过频繁更换敷料程序产生额外的并发症。受对工程“智能”绷带需求的启发，这项研究产生了一种多方面的方法来开发一种无粘合剂、可渗透的多路传感器系统。电子细胞外基质 (e-ECM) 平台能够在灵活、可拉伸和可渗透的生物集成平台上实时监测化学和物理变化。多路传感器构建在柔软、薄且微纤维的硅树脂基底之上，以产生保形、无粘合剂、对流或扩散的伤口渗出液流动，以及被动气体转移，以增加细胞上皮化和无阻碍的物理和化学传感器监测。伤口部位。该平台模拟天然表皮力学和物理细胞外基质结构，以实现紧密的生物整合。多生物传感器阵列可以连续检查与伤口愈合状态相关的炎症生物标志物，例如乳酸、葡萄糖、pH、氧气和伤口温度。此外，还加入了一个加热元件，以保持伤口床的最佳热条件。e-ECM 电化学生物传感器在体外、磷酸盐缓冲盐水中和离体进行了测试，伤口渗出液内。“智能”伤口绷带在微纤维平台上结合了生物相容性材料、治疗和监测方式，用于复杂的伤口动态控制和分析。

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Adhesive-Free, Stretchable, and Permeable Multiplex Wound Care Platform

The wound healing process remains a poorly understood biological mechanism. The high morbidity and mortality rates associated with chronic wounds are a critical concern to the health care industry. Although assessments and treatment options exist, these strategies have primarily relied on static wound dressings that do not consider the dynamic physicochemical microenvironment and can often create additional complications through the frequent dressing changing procedure. Inspired by the need for engineering “smart” bandages, this study resulted in a multifaceted approach to developing an adhesive-free, permeable, and multiplex sensor system. The electronic-extracellular matrix (e-ECM) platform is capable of noninvasively monitoring chemical and physical changes in real-time on a flexible, stretchable, and permeable biointegrated platform. The multiplex sensors are constructed atop a soft, thin, and microfibrous substrate of silicone to yield a conformal, adhesive-free, convective, or diffusive wound exudate flow, and passive gas transfer for increased cellular epithelization and unobstructed physical and chemical sensor monitoring at the wound site. This platform emulates the native epidermal mechanics and physical extracellular matrix architecture for intimate bio-integration. The multiple biosensor array can continuously examine inflammatory biomarker such as lactate, glucose, pH, oxygen, and wound temperature that correlates to the wound healing status. Additionally, a heating element was incorporated to maintain the optimal thermal conditions at the wound bed. The e-ECM electrochemical biosensors were tested in vitro, within phosphate-buffered saline, and ex vivo, within wound exudate. The “smart” wound bandage combines biocompatible materials, treatments, and monitoring modalities on a microfibrous platform for complex wound dynamic control and analysis.

更新日期：2022-07-07

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