Acetyl-CoA synthetase 2 (ACSS2), an important member of the acetyl-CoA synthetase (ACSS) family, can catalyze the conversion of acetate to acetyl coenzyme A (acetyl-CoA). Currently, acetyl-CoA is considered an important intermediate metabolite in the metabolism of energy substrates. In addition, nutrients converge through acetyl-CoA into a common metabolic pathway, the tricarboxylic acid cycle and oxidative phosphorylation. Not only does ACSS2 play a crucial role in material energy metabolism, it is also involved in the regulation of various acetylation processes, such as regulation of histone and transcription factor acetylation. ACSS2-mediated regulation of acetylation is related to substance metabolism and tumorigenesis. In mammalian cells, ACSS2 utilizes intracellular acetate to synthesize acetyl-CoA, a step in the process of DNA and histone acetylation. In addition, studies in tumors have shown that cancer cells adapt to the growth conditions in the tumor microenvironment (TME) by activating or increasing the expression level of ACSS2 under metabolic stress. Therefore, this review mainly outlines the role of ACSS2 in substance metabolism and tumors and provides insights useful for investigating ACSS2 as a therapeutic target.

乙酰辅酶 A 合成酶 2 (ACSS2) 是乙酰辅酶 A 合成酶 (ACSS) 家族的重要成员，可催化乙酸转化为乙酰辅酶 A (乙酰辅酶 A)。目前，乙酰辅酶A被认为是能量底物代谢中的重要中间代谢物。此外，营养物质通过乙酰辅酶A 汇聚到共同的代谢途径、三羧酸循环和氧化磷酸化中。ACSS2 不仅在物质能量代谢中起着至关重要的作用，它还参与各种乙酰化过程的调节，如组蛋白和转录因子乙酰化的调节。ACSS2 介导的乙酰化调节与物质代谢和肿瘤发生有关。在哺乳动物细胞中，ACSS2 利用细胞内醋酸盐合成乙酰辅酶A，DNA和组蛋白乙酰化过程中的一个步骤。此外，对肿瘤的研究表明，癌细胞通过在代谢应激下激活或增加 ACSS2 的表达水平来适应肿瘤微环境 (TME) 的生长条件。因此，本综述主要概述了 ACSS2 在物质代谢和肿瘤中的作用，并为研究 ACSS2 作为治疗靶点提供了有用的见解。