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Three-component synthesis of 5,6-dihydropyrrolo[2,1-a]isoquinolines from 1-aroyl-3,4-dihydroisoquinolines, electron-deficient alkynes and NH-acids
Tetrahedron Letters ( IF 1.5 ) Pub Date : 2022-07-06 , DOI: 10.1016/j.tetlet.2022.153991
Almira R. Miftyakhova , Matvey B. Sidakov , Tatiana N. Borisova , Valentina V. Ilyushenkova , Artem N. Fakhrutdinov , Elena A. Sorokina , Alexey V. Varlamov , Leonid G. Voskressensky

The three-component domino reaction involving 1-aroyl-3,4-dihydroisoquinolines, terminal alkynes, and cyclic NH-acids is a new method for the synthesis of 5,6-dihydropyrrolo[2,1-a]isoquinolines containing in position 3, cyclic nitrogen-containing fragments. The transformation is performed under microwave irradiation in dry acetonitrile at 130 °C.



中文翻译:

由 1-芳酰基-3,4-二氢异喹啉、缺电子炔烃和 NH-酸三组分合成 5,6-二氢吡咯并[2,1-a]异喹啉

涉及1-芳酰基-3,4-二氢异喹啉、末端炔烃和环状NH-酸的三组分多米诺反应是合成3位含5,6-二氢吡咯并[2,1- a ]异喹啉的新方法,环状含氮片段。转化是在微波辐射下在 130 °C 的干燥乙腈中进行的。

更新日期:2022-07-06
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