Excited-state palladium-catalysed reductive alkylation of imines: scope and mechanism,Chemical Science

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Excited-state palladium-catalysed reductive alkylation of imines: scope and mechanism
Chemical Science ( IF 7.6 ) Pub Date : 2022-07-07 , DOI: 10.1039/d2sc02363f
Rajesh Kancherla ₁ , Krishnamoorthy Muralirajan ₁ , Magnus Rueping ₁

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Palladium catalysis induced by visible-light irradiation is a promising tool for promoting unusual chemical transformations. We describe the development of excited-state palladium-catalyzed reductive alkylation of imines with alkyl bromides. The new methodology shows broad functional group tolerance and can additionally be applied in the direct three-component reaction of aldehydes, anilines, and alkyl bromides to give the alkyl amines under mild reaction conditions. Time-resolved photoluminescence experiments allowed the determination of the excited-state reaction kinetics and indicate that the reaction is proceeding via the inner-sphere electron transfer mechanism.

中文翻译：

激发态钯催化的亚胺还原烷基化：范围和机理

可见光照射诱导的钯催化是促进不寻常化学转化的有前途的工具。我们描述了激发态钯催化的亚胺与烷基溴的还原烷基化的发展。新方法显示出广泛的官能团耐受性，还可应用于醛、苯胺和烷基溴的直接三组分反应，在温和的反应条件下生成烷基胺。时间分辨光致发光实验可以确定激发态反应动力学，并表明反应是通过内球电子转移机制进行的。

更新日期：2022-07-07

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