A one-pot strategy for the synthesis of 3-hydroxy-3-furylisoindolinone derivatives is reported. The reaction proceeds via a copper-catalyzed oxidative cascade inter-molecular double cyclization of 2-iodobenzamide derivatives and propargyl dicarbonyl compounds in the presence of oxygen. The strategy involves several reactions including cyclization/coupling/double C(sp3)−H functionalization in a cascade manner. A wide range of 2-iodobenzamide substrates containing different substituents as well as various propargyldicarbonyl compounds and propargylsulfonyl aryl ketones can be used to access a variety of 3-hydroxy-3-furylisoindolinone derivatives.

中文翻译：

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铜催化氧化级联分子间双环化 2-碘苯甲酰胺衍生物和炔丙基二羰基化合物获得 3-Hydroxy-3-Furylisoindolinone 衍生物

报道了一种合成 3-羟基-3-呋喃基异吲哚啉酮衍生物的一锅法。该反应在氧气存在下通过2-碘苯甲酰胺衍生物和炔丙基二羰基化合物的铜催化氧化级联分子间双环化进行。该策略涉及多个反应，包括级联方式的环化/偶联/双 C( sp3 ) -H官能化。广泛的含有不同取代基的 2-碘苯甲酰胺底物以及各种炔丙基二羰基化合物和炔丙基磺酰基芳基酮可用于获得各种 3-羟基-3-呋喃基异吲哚啉酮衍生物。