从突尼斯地衣物种中分离的化合物的抗炎潜力,Chemistry & Biodiversity

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从突尼斯地衣物种中分离的化合物的抗炎潜力
Chemistry & Biodiversity ( IF 2.3 ) Pub Date : 2022-07-05 , DOI: 10.1002/cbdv.202200134
Mohamed Mendili ₁ , Ayda Khadhri ₁ , Jouda Mediouni-Ben Jemâa ₂ , Anna Andolfi _{3,

4} , Immacolata Tufano ₃ , Samira Aschi-Smiti ₁ , Marina DellaGreca ₃

Affiliation

地衣特殊的共生结构使其能够产生生物活性物质。它们在历史上因其美学和药用价值而得到认可。此外，近年来，由于其丰富的次生代谢产物，它们在香水、染色和药理学等各个领域都有表现。根据我们的研究，从Parmotrema hypoleucinum、Roccella phycopsis和Xanthoria parietina的有机提取物中分离出四种化合物并通过光谱研究分别鉴定为 atranorin、(+)-iso-usnic acid、methyl orsellinate 和 parietin。在不同浓度的 RAW 264.7 巨噬细胞上评估了地衣提取物和纯化合物的抗炎作用。在 25 μg/mL 时，所有处理过的样品均未显示对细胞活力的任何影响。Atranorin 和 (+)-iso-usnic acid 对脂多糖 (LPS) 刺激的巨噬细胞中的一氧化氮 (NO) 水平有抑制作用。使用 Griess 试剂测量一氧化氮 (NO) 的产生，atranorin 和 (+)-iso-usnic acid 显示出高抗炎潜力（在 25 μg/mL 时分别为 75.99 % 和 57.27 %）。另一方面，海藻酸甲酯和三种地衣的有机提取物显示出良好的抗炎活性，从 25 μg/mL 的 29.16 % 到 100 μg/mL 的 86.91 %。

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Anti-Inflammatory Potential of Compounds Isolated from Tunisian Lichens Species

The lichen's special symbiotic structure enables it to produce bioactive substances. They have historically been recognized for their aesthetic and medicinal benefits. Furthermore, in recent years, they have performed in various fields, including perfumery, dyeing, and pharmacology due to their rich secondary metabolites. From our study, four compounds were isolated from organic extracts of Parmotrema hypoleucinum, Roccella phycopsis, and Xanthoria parietina and identified by spectroscopic investigation as atranorin, (+)-iso-usnic acid, methyl orsellinate, and parietin, respectively. The anti-inflammatory effects of lichens extracts, and pure compounds were evaluated on RAW 264.7 macrophages cells at different concentrations. At 25 μg/mL all treated samples did not show any effect on cell viability. Atranorin and (+)-iso-usnic acid showed an inhibitory effect on nitric oxide (NO) levels in lipopolysaccharide (LPS)-stimulated macrophages. Nitric oxide (NO) production was measured using Griess reagent, atranorin and (+)-iso-usnic acid showed a high anti-inflammatory potential (75.99 % and 57.27 % at 25 μg/mL). On the other hand, methyl orsellinate and the organic extracts of three lichens showed good anti-inflammatory activity ranging from 29.16 % at 25 μg/mL to 86.91 % at 100 μg/mL.

更新日期：2022-07-05

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