An Activity-Based Fluorescent Probe for Imaging Fluctuations of Peroxynitrite (ONOO−) in the Alzheimer's Disease Brain,Angewandte Chemie International Edition

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An Activity-Based Fluorescent Probe for Imaging Fluctuations of Peroxynitrite (ONOO−) in the Alzheimer's Disease Brain
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2022-07-05 , DOI: 10.1002/anie.202206894
Pengzhan Wang ₁ , Le Yu ₂ , Jiankang Gong ₁ , Jianhua Xiong ₃ , Soyu Zi ₂ , Hua Xie ₄ , Fan Zhang ₁ , Zhiqiang Mao _{1,

2} , Zhihong Liu _{1,

3} , Jong Seung Kim ₂

Affiliation

Combining the ONOO⁻-initiated cascade reactions of a novel chemical trigger and a new NIR emissive Rhodol fluorophore, an activity-based NIR fluorescent probe for ONOO⁻ in Alzheimer's disease (AD) brains was constructed. Real-time imaging of ONOO⁻ in AD mice and age-dependent accumulation of ONOO⁻ in AD mouse brains have been demonstrated with the probe.

中文翻译：

一种基于活动的荧光探针，用于对阿尔茨海默病大脑中过氧亚硝酸盐 (ONOO-) 的波动进行成像

结合 ONOO ^-引发的新型化学触发器和新的 NIR 发射 Rhodol 荧光团的级联反应，构建了一种用于阿尔茨海默病 (AD) 大脑中ONOO ^{-的基于活性的 NIR 荧光探针。}探针已经证实了AD 小鼠中 ONOO ^-的实时成像和 AD 小鼠大脑中 ONOO ^-的年龄依赖性积累。

更新日期：2022-07-05

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